Translational studies in the complex role of neurotransmitter systems in anxiety and anxiety disorders

Jocelien D A Olivier, Berend Olivier*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

3 Citations (Scopus)

Abstract

Discovery of innovative anxiolytics is severely hampering. Existing anxiolytics are developed decades ago and are still the therapeutics of choice. Moreover, lack of new drug targets forecasts a severe jeopardy in the future treatment of the huge population of CNS-diseased patients. We simply lack the knowledge on what is wrong in brains of anxious people (normal and diseased). Translational research, based on interacting clinical and preclinical research, is extremely urgent. In this endeavor, genetic and genomic approaches are part of the spectrum of contributing factors. We focus on three druggable targets: serotonin transporter, 5-HT1A, and GABAA receptors. It is still uncertain whether and how these targets are involved in normal and diseased anxiety processes. For serotonergic anxiolytics, the slow onset of action points to indirect effects leading to plasticity changes in brain systems leading to reduced anxiety. For GABAA benzodiazepine drugs, acute anxiolytic effects are found indicating primary mechanisms directly influencing anxiety processes. Close translational collaboration between fundamental academic and discovery research will lead to badly needed breakthroughs in the search for new anxiolytics.

Original languageEnglish
Title of host publicationAnxiety Disorders
EditorsY.K. Kim
Place of PublicationSingapore
PublisherSpringer
Chapter8
Pages121-140
Number of pages20
ISBN (Electronic)978-981-32-9705-0
ISBN (Print)978-981-32-9704-3
DOIs
Publication statusPublished - 2020

Publication series

NameAdvances in experimental medicine and biology
Volume1191
ISSN (Print)0065-2598

Keywords

  • Anti-Anxiety Agents/pharmacology
  • Anxiety/drug therapy
  • Anxiety Disorders/drug therapy
  • Drug Discovery
  • Humans
  • Neurotransmitter Agents/metabolism
  • Translational Medical Research
  • STRESS-INDUCED HYPERTHERMIA
  • SEROTONIN TRANSPORTER GENE
  • ANIMAL-MODELS
  • 5-HT1A RECEPTOR
  • NEURAL CIRCUITS
  • MICE
  • KNOCKOUT
  • RAT
  • ANTIDEPRESSANT
  • SENSITIVITY

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