Transmissiepatronen van hepatitis B-virus in Nederland, 2004

F D H Koedijk; R van Houdt; E L M Op de Coul; N H T M Dukers; H G M Niesters; M C Mostert; J H Richardus; R A de Man; G J J van Doornum; J A R van den Hoek; M J W van de Laar; R A Coutinho; S M Bruisten; H J Boot

Transmissiepatronen van hepatitis B-virus in Nederland, 2004

Translated title of the contribution: Hepatitis B virus transmission patterns in the Netherlands, 2004

F D H Koedijk, R van Houdt, E L M Op de Coul, N H T M Dukers, H G M Niesters, M C Mostert, J H Richardus, R A de Man, G J J van Doornum, J A R van den Hoek, M J W van de Laar, R A Coutinho, S M Bruisten, H J Boot

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To gain insight into hepatitis B virus (HBV) transmission in the Netherlands.

DESIGN: Descriptive.

METHOD: During 2004, epidemiological data and blood samples (if available) were collected for all reported cases of acute HBV infections in the Netherlands. Following DNA isolation and amplification a 648 base pairs fragment of the HBV S gene was sequenced and subjected to phylogenetic analysis. The sequencing details were also linked to epidemiological information.

RESULTS: In 2004, 291 cases ofacute HBV infections were reported. Blood samples were received from 171 patients (59%), and the genotype could be determined for 158 patients (54%). 6 genotypes were identified: A (64%), B (3%), C (3%), D (21%), E (5%) and F (4%). Of all patients with genotype A, 52% had been infected via homosexual or bisexual contact and 16% via heterosexual contact. Of all patients with genotype D, 42% had been infected via heterosexual contact and 15% via homosexual or bisexual contact. The genotype A cluster was extremely homogeneous with many identical sequences, while genotype B-E clusters were more heterogeneous. 4 identical sequences were found within genotype F, but the patients could not be epidemiologically linked.

CONCLUSION: Sexual transmission, particularly via homosexual or bisexual contact in men, formed the most important risk factor for acquiring an acute HBV infection. Genotype A was predominant in the Netherlands, especially among homosexual or bisexual men. Most infections within genotype D occurred as a result of heterosexual contact. The results show that there was ongoing transmission of HBV in homosexual or bisexual men, while in heterosexuals more cases of new introduction were seen, possibly via chronic carriers from areas where HBV is endemic.

Translated title of the contribution	Hepatitis B virus transmission patterns in the Netherlands, 2004
Original language	Dutch
Pages (from-to)	2673-80
Number of pages	8
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	152
Issue number	49
Publication status	Published - 6-Dec-2008

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Koedijk, F. D. H., van Houdt, R., Op de Coul, E. L. M., Dukers, N. H. T. M., Niesters, H. G. M., Mostert, M. C., Richardus, J. H., de Man, R. A., van Doornum, G. J. J., van den Hoek, J. A. R., van de Laar, M. J. W., Coutinho, R. A., Bruisten, S. M., & Boot, H. J. (2008). Transmissiepatronen van hepatitis B-virus in Nederland, 2004. Nederlands Tijdschrift voor Geneeskunde, 152(49), 2673-80.

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title = "Transmissiepatronen van hepatitis B-virus in Nederland, 2004",

abstract = "OBJECTIVE: To gain insight into hepatitis B virus (HBV) transmission in the Netherlands.DESIGN: Descriptive.METHOD: During 2004, epidemiological data and blood samples (if available) were collected for all reported cases of acute HBV infections in the Netherlands. Following DNA isolation and amplification a 648 base pairs fragment of the HBV S gene was sequenced and subjected to phylogenetic analysis. The sequencing details were also linked to epidemiological information.RESULTS: In 2004, 291 cases ofacute HBV infections were reported. Blood samples were received from 171 patients (59%), and the genotype could be determined for 158 patients (54%). 6 genotypes were identified: A (64%), B (3%), C (3%), D (21%), E (5%) and F (4%). Of all patients with genotype A, 52% had been infected via homosexual or bisexual contact and 16% via heterosexual contact. Of all patients with genotype D, 42% had been infected via heterosexual contact and 15% via homosexual or bisexual contact. The genotype A cluster was extremely homogeneous with many identical sequences, while genotype B-E clusters were more heterogeneous. 4 identical sequences were found within genotype F, but the patients could not be epidemiologically linked.CONCLUSION: Sexual transmission, particularly via homosexual or bisexual contact in men, formed the most important risk factor for acquiring an acute HBV infection. Genotype A was predominant in the Netherlands, especially among homosexual or bisexual men. Most infections within genotype D occurred as a result of heterosexual contact. The results show that there was ongoing transmission of HBV in homosexual or bisexual men, while in heterosexuals more cases of new introduction were seen, possibly via chronic carriers from areas where HBV is endemic.",

author = "Koedijk, {F D H} and {van Houdt}, R and {Op de Coul}, {E L M} and Dukers, {N H T M} and Niesters, {H G M} and Mostert, {M C} and Richardus, {J H} and {de Man}, {R A} and {van Doornum}, {G J J} and {van den Hoek}, {J A R} and {van de Laar}, {M J W} and Coutinho, {R A} and Bruisten, {S M} and Boot, {H J}",

year = "2008",

month = dec,

day = "6",

language = "Dutch",

volume = "152",

pages = "2673--80",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "NLM (Medline)",

number = "49",

}

TY - JOUR

T1 - Transmissiepatronen van hepatitis B-virus in Nederland, 2004

AU - Koedijk, F D H

AU - van Houdt, R

AU - Op de Coul, E L M

AU - Dukers, N H T M

AU - Niesters, H G M

AU - Mostert, M C

AU - Richardus, J H

AU - de Man, R A

AU - van Doornum, G J J

AU - van den Hoek, J A R

AU - van de Laar, M J W

AU - Coutinho, R A

AU - Bruisten, S M

AU - Boot, H J

PY - 2008/12/6

Y1 - 2008/12/6

N2 - OBJECTIVE: To gain insight into hepatitis B virus (HBV) transmission in the Netherlands.DESIGN: Descriptive.METHOD: During 2004, epidemiological data and blood samples (if available) were collected for all reported cases of acute HBV infections in the Netherlands. Following DNA isolation and amplification a 648 base pairs fragment of the HBV S gene was sequenced and subjected to phylogenetic analysis. The sequencing details were also linked to epidemiological information.RESULTS: In 2004, 291 cases ofacute HBV infections were reported. Blood samples were received from 171 patients (59%), and the genotype could be determined for 158 patients (54%). 6 genotypes were identified: A (64%), B (3%), C (3%), D (21%), E (5%) and F (4%). Of all patients with genotype A, 52% had been infected via homosexual or bisexual contact and 16% via heterosexual contact. Of all patients with genotype D, 42% had been infected via heterosexual contact and 15% via homosexual or bisexual contact. The genotype A cluster was extremely homogeneous with many identical sequences, while genotype B-E clusters were more heterogeneous. 4 identical sequences were found within genotype F, but the patients could not be epidemiologically linked.CONCLUSION: Sexual transmission, particularly via homosexual or bisexual contact in men, formed the most important risk factor for acquiring an acute HBV infection. Genotype A was predominant in the Netherlands, especially among homosexual or bisexual men. Most infections within genotype D occurred as a result of heterosexual contact. The results show that there was ongoing transmission of HBV in homosexual or bisexual men, while in heterosexuals more cases of new introduction were seen, possibly via chronic carriers from areas where HBV is endemic.

AB - OBJECTIVE: To gain insight into hepatitis B virus (HBV) transmission in the Netherlands.DESIGN: Descriptive.METHOD: During 2004, epidemiological data and blood samples (if available) were collected for all reported cases of acute HBV infections in the Netherlands. Following DNA isolation and amplification a 648 base pairs fragment of the HBV S gene was sequenced and subjected to phylogenetic analysis. The sequencing details were also linked to epidemiological information.RESULTS: In 2004, 291 cases ofacute HBV infections were reported. Blood samples were received from 171 patients (59%), and the genotype could be determined for 158 patients (54%). 6 genotypes were identified: A (64%), B (3%), C (3%), D (21%), E (5%) and F (4%). Of all patients with genotype A, 52% had been infected via homosexual or bisexual contact and 16% via heterosexual contact. Of all patients with genotype D, 42% had been infected via heterosexual contact and 15% via homosexual or bisexual contact. The genotype A cluster was extremely homogeneous with many identical sequences, while genotype B-E clusters were more heterogeneous. 4 identical sequences were found within genotype F, but the patients could not be epidemiologically linked.CONCLUSION: Sexual transmission, particularly via homosexual or bisexual contact in men, formed the most important risk factor for acquiring an acute HBV infection. Genotype A was predominant in the Netherlands, especially among homosexual or bisexual men. Most infections within genotype D occurred as a result of heterosexual contact. The results show that there was ongoing transmission of HBV in homosexual or bisexual men, while in heterosexuals more cases of new introduction were seen, possibly via chronic carriers from areas where HBV is endemic.

UR - http://cat.inist.fr/?aModele=afficheN&cpsidt=20902906

M3 - Article

C2 - 19137968

SN - 0028-2162

VL - 152

SP - 2673

EP - 2680

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 49

ER -

Transmissiepatronen van hepatitis B-virus in Nederland, 2004

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