Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

Yvette A. H. Matser; Matty L. Terpstra; Silvio Nadalin; George D. Nossent; Jan de Boer; Barbara C. van Bemmel; Susanne van Eeden; Klemens Budde; Susanne Brakemeier; Frederike J. Bemelman

doi:10.1111/ajt.14766

Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

Yvette A. H. Matser, Matty L. Terpstra, Silvio Nadalin, George D. Nossent, Jan de Boer, Barbara C. van Bemmel, Susanne van Eeden, Klemens Budde, Susanne Brakemeier, Frederike J. Bemelman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16months to 6years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.

In this case report, the authors describe the unfortunate event of breast cancer transmission from a multi-organ donor to four recipients.

Original language	English
Pages (from-to)	1810-1814
Number of pages	5
Journal	American Journal of Transplantation
Volume	18
Issue number	7
DOIs	https://doi.org/10.1111/ajt.14766
Publication status	Published - Jul-2018

Keywords

clinical decision-making
clinical research
practice
complication: malignant
donors and donation: deceased
organ transplantation in general

Access to Document

10.1111/ajt.14766

Cite this

Matser, Yvette A. H. ; Terpstra, Matty L. ; Nadalin, Silvio ; Nossent, George D. ; de Boer, Jan ; van Bemmel, Barbara C. ; van Eeden, Susanne ; Budde, Klemens ; Brakemeier, Susanne ; Bemelman, Frederike J. / Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients. In: American Journal of Transplantation. 2018 ; Vol. 18, No. 7. pp. 1810-1814.

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title = "Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients",

abstract = "We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16months to 6years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.In this case report, the authors describe the unfortunate event of breast cancer transmission from a multi-organ donor to four recipients.",

keywords = "clinical decision-making, clinical research, practice, complication: malignant, donors and donation: deceased, organ transplantation in general",

author = "Matser, {Yvette A. H.} and Terpstra, {Matty L.} and Silvio Nadalin and Nossent, {George D.} and {de Boer}, Jan and {van Bemmel}, {Barbara C.} and {van Eeden}, Susanne and Klemens Budde and Susanne Brakemeier and Bemelman, {Frederike J.}",

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Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients. / Matser, Yvette A. H.; Terpstra, Matty L.; Nadalin, Silvio; Nossent, George D.; de Boer, Jan; van Bemmel, Barbara C.; van Eeden, Susanne; Budde, Klemens; Brakemeier, Susanne; Bemelman, Frederike J.

In: American Journal of Transplantation, Vol. 18, No. 7, 07.2018, p. 1810-1814.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - de Boer, Jan

AU - van Bemmel, Barbara C.

AU - van Eeden, Susanne

AU - Budde, Klemens

AU - Brakemeier, Susanne

AU - Bemelman, Frederike J.

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AB - We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16months to 6years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.In this case report, the authors describe the unfortunate event of breast cancer transmission from a multi-organ donor to four recipients.

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