Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles

Denisa Vargova, Juana M. Perez, Syuzanna R. Harutyunyan, Radovan Sebesta*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
43 Downloads (Pure)

Abstract

Here we show trapping of chiral enolates with carbenium ions, Michael acceptors, and bromine. Silyl ketene aminals, disilyl acetals, and aza-enolates were obtained via Lewis acid mediated enantioselective conjugate addition of Grignard reagents to unsaturated amides, carboxylic acids and alkenyl heterocycles.

Original languageEnglish
Pages (from-to)11766-11769
Number of pages4
JournalChemical Communications
Volume55
Issue number78
DOIs
Publication statusPublished - 7-Oct-2019

Keywords

  • ASYMMETRIC-SYNTHESIS
  • ALKYLATION
  • NUCLEOPHILICITY
  • REACTIVITY
  • SCALES

Cite this