Treatment delay and response rate in first episode psychosis

A Wunderink; FJ Nienhuis; S Sytema; D Wiersma

doi:10.1111/j.1600-0447.2005.00685.x

Treatment delay and response rate in first episode psychosis

A Wunderink^*, FJ Nienhuis, S Sytema, D Wiersma

^*Corresponding author for this work

Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)

Research output: Contribution to journal › Article › Academic › peer-review

53 Citations (Scopus)

Abstract

Objective: There is no consistent evidence of long duration of untreated psychosis (DUP) predicting long time to response (TTR) in first psychosis. This Study aims to investigate the predictors of DUP and TTR in a first episode patient population.

Method: An epidemiologically representative sample of 157 non-affective first psychotic episode patients was interviewed and followed-up for at least half a year.

Results: The mean DUP was 46 weeks, the median 31 days. Long DUP was associated with being unemployed before treatment and male gender. Short DUP, having a job, and living with a partner before treatment predicted early response.

Conclusion: Early intervention likely improves short-term treatment response in first episode psychosis. The best strategy to reduce DUP probably is to direct attention to the Substantial number of patients who do not engage in regular treatment.

Original language	English
Pages (from-to)	332-339
Number of pages	8
Journal	Acta Psychiatrica Scandinavica
Volume	113
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0447.2005.00685.x
Publication status	Published - Apr-2006

Keywords

psychotic disorders
schizophrenia
early diagnosis
UNTREATED PSYCHOSIS
1ST-EPISODE PSYCHOSIS
SCHIZOPHRENIA
DURATION
PREDICTORS
ASSOCIATION
DISORDERS
IMPACT
SCALE

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title = "Treatment delay and response rate in first episode psychosis",

abstract = "Objective: There is no consistent evidence of long duration of untreated psychosis (DUP) predicting long time to response (TTR) in first psychosis. This Study aims to investigate the predictors of DUP and TTR in a first episode patient population.Method: An epidemiologically representative sample of 157 non-affective first psychotic episode patients was interviewed and followed-up for at least half a year.Results: The mean DUP was 46 weeks, the median 31 days. Long DUP was associated with being unemployed before treatment and male gender. Short DUP, having a job, and living with a partner before treatment predicted early response.Conclusion: Early intervention likely improves short-term treatment response in first episode psychosis. The best strategy to reduce DUP probably is to direct attention to the Substantial number of patients who do not engage in regular treatment.",

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author = "A Wunderink and FJ Nienhuis and S Sytema and D Wiersma",

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doi = "10.1111/j.1600-0447.2005.00685.x",

language = "English",

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AU - Wunderink, A

AU - Nienhuis, FJ

AU - Sytema, S

AU - Wiersma, D

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N2 - Objective: There is no consistent evidence of long duration of untreated psychosis (DUP) predicting long time to response (TTR) in first psychosis. This Study aims to investigate the predictors of DUP and TTR in a first episode patient population.Method: An epidemiologically representative sample of 157 non-affective first psychotic episode patients was interviewed and followed-up for at least half a year.Results: The mean DUP was 46 weeks, the median 31 days. Long DUP was associated with being unemployed before treatment and male gender. Short DUP, having a job, and living with a partner before treatment predicted early response.Conclusion: Early intervention likely improves short-term treatment response in first episode psychosis. The best strategy to reduce DUP probably is to direct attention to the Substantial number of patients who do not engage in regular treatment.

AB - Objective: There is no consistent evidence of long duration of untreated psychosis (DUP) predicting long time to response (TTR) in first psychosis. This Study aims to investigate the predictors of DUP and TTR in a first episode patient population.Method: An epidemiologically representative sample of 157 non-affective first psychotic episode patients was interviewed and followed-up for at least half a year.Results: The mean DUP was 46 weeks, the median 31 days. Long DUP was associated with being unemployed before treatment and male gender. Short DUP, having a job, and living with a partner before treatment predicted early response.Conclusion: Early intervention likely improves short-term treatment response in first episode psychosis. The best strategy to reduce DUP probably is to direct attention to the Substantial number of patients who do not engage in regular treatment.

KW - psychotic disorders

KW - schizophrenia

KW - early diagnosis

KW - UNTREATED PSYCHOSIS

KW - 1ST-EPISODE PSYCHOSIS

KW - SCHIZOPHRENIA

KW - DURATION

KW - PREDICTORS

KW - ASSOCIATION

KW - DISORDERS

KW - IMPACT

KW - SCALE

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DO - 10.1111/j.1600-0447.2005.00685.x

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EP - 339

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 4

ER -

Treatment delay and response rate in first episode psychosis

Abstract

Keywords

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