Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening

DS Postma*, C Sevette, Y Martinat, N Schlosser, J Aumann, H Kafe

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

129 Citations (Scopus)

Abstract

The study addressed the question whether the novel inhaled prodrug corticosteroid ciclesonide is equally effective when inhaled in the morning compared to the evening.

For this purpose a double-blind, randomized, parallel group study was initiated in which 209 asthmatic patients (forced expiratory volume in one second=50-90% predicted) inhaled either 200 mug ciclesonide in the morning or in the evening, for 8 weeks. Efficacy was assessed by means of spirometry as well as daily recordings of morning and evening Desk expiratory flow (PEF), symptoms and use of rescue medication. The 24-h urinary cortisol excretion was measured to evaluate any effect on hypothalamic-pituitary-adrenol axis.

Ciclesonide significantly improved asthma control. Morning and evening administration was shown to be equally effective for the different spirometry variables, evening PEF, symptoms, use of rescue medication and number of asthma exacerbations. Regarding morning PEF, the improvements after evening dosing were more prominent and equivalence of morning and evening administration could not be demonstrated, No relevant influence on cortisol excretion was found.

Overall, the study indicates that ciclesonide can be given either in the morning or in the evening to meet the patients' preference and individual medical needs, although evening administration may lead to a more pronounced improvement in morning peak expiratory flow.

Original languageEnglish
Pages (from-to)1083-1088
Number of pages6
JournalEuropean Respiratory Journal
Volume17
Issue number6
Publication statusPublished - Jun-2001

Keywords

  • asthma
  • dosing time
  • inhaled steroids
  • once daily
  • NOCTURNAL ASTHMA
  • MODERATE ASTHMA
  • DRUG EFFICACY
  • BUDESONIDE
  • CHRONOTHERAPY
  • STEROIDS
  • SINGLE

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