Treatment of Diabetes with Encapsulated Islets

Paul de Vos*, Milica Spasojevic, Marijke M. Faas

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

53 Citations (Scopus)

Abstract

Cell encapsulation has been proposed for the treatment of a wide variety of diseases since it allows for transplantation of cells in the absence of undesired immunosuppression. The technology has been proposed to be a solution for the treatment of diabetes since it potentially allows a mandatory minute-to-minute regulation of glucose levels without side-effects. Encapsulation is based on the principle that transplanted tissue is protected for the host immune system by a semipermeable capsule. Many different concepts of capsules have been tested. During the past two decades three major approaches of encapsulation have been studied. These include (i) intravascular macrocapsules, which arc anastomosed to the vascular system as AV shunt, (ii) extravascular macrocapsules, which are mostly diffusion chambers transplanted at different sites and (iii) extravascular microcapsules transplanted in the peritoneal cavity. The advantages and pitfalls of the three approaches are discussed and compared in view of applicability in clinical islet transplantation.

Original languageEnglish
Title of host publicationTHERAPEUTIC APPLICATIONS OF CELL MICROENCAPSULATION
EditorsJL Pedraz, G Orive
Place of PublicationBERLIN
PublisherSpringer
Pages38-53
Number of pages16
ISBN (Print)978-1-4419-5785-6
Publication statusPublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSPRINGER-VERLAG BERLIN
Volume670
ISSN (Print)0065-2598

Keywords

  • ALGINATE-POLYLYSINE MICROCAPSULES
  • HYBRID ARTIFICIAL PANCREAS
  • MOLECULAR-WEIGHT CUTOFF
  • IN-VIVO PERFORMANCE
  • LONG-TERM
  • BIOARTIFICIAL PANCREAS
  • PLL CAPSULES
  • PORCINE ISLETS
  • MICROENCAPSULATED ISLETS
  • CELL ENCAPSULATION

Cite this