Treatment of theophylline intoxication using continuous venovenous haemofiltration

J.J. Koeijers, C.L. Verhoeven, H.H. Boersma, W.N.K.A van Mook

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    Theophylline intoxication can cause serious complications such as seizures, cardiac arrhythmias and eventually cardiac arrest. Because of these potentially life-threatening clinical manifestations of theophylline intoxication, treatment methods that rapidly eliminate the drug are essential. These methods include oral administration of activated charcoal and extracorporeal drug removal. Less life-threatening symptoms like refractory vomiting, that seriously interfere with the oral administration of activated charcoal may necessitate use of extracorporeal methods for drug removal as well. We present a case report on a 77-year-old female patient with theophylline intoxication who was treated by continuous venovenous haemofiltration because of refractory vomiting along with haemodynamic instability. Considering the better availability and good clinical efficacy of continuous venovenous haemofiltration in theophylline intoxication, this method may be considered if other methods of drug removal cannot be applied. Copyright © 2008, Nederlandse Vereniging voor Intensive Care. All Rights Reserved.
    Original languageEnglish
    Pages (from-to)32-34
    Number of pages3
    JournalNetherlands Journal of Critical Care
    Issue number1
    Publication statusPublished - 17-Mar-2008


    • Dialysis
    • Haemofiltration
    • Poisoning
    • Refractory vomiting
    • Theophylline
    • acetylcysteine
    • activated carbon
    • metoclopramide
    • ondansetron
    • paracetamol
    • potassium
    • sodium sulfate
    • theophylline
    • aged
    • anamnesis
    • article
    • blood oxygen tension
    • blood pressure
    • case report
    • continuous hemofiltration
    • diaphoresis
    • drug blood level
    • drug intoxication
    • electrocardiography
    • female
    • hemodynamics
    • human
    • laboratory test
    • lung disease
    • nausea
    • physical examination
    • pulse rate
    • sinus tachycardia
    • treatment outcome
    • vomiting

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