Abstract
PURPOSE: Two young females with well-documented Crohn's disease and nonhealing perineal wounds following proctectomy compatible with "metastatic Crohn's disease" are described, We hypothesized that metastatic Crohn's disease would be a tumor necrosis factor-dependent inflammatory-reaction and have treated these two patients with the anti-tumor necrosis factor chimeric monoclonal antibody, cA2. MAIN FINDINGS: Administration of cA2 was followed by a rapid reduction of subjective and objective parameters of inflammation and caused a substantial reduction of the wound size, CONCLUSION: These preliminary data are consistent with a tumor necrosis factor-dependent inflammatory cause of Crohn's disease and its extraintestinal manifestations and provide support for targeting tumor necrosis factor in this condition.
| Original language | English |
|---|---|
| Pages (from-to) | 98-102 |
| Number of pages | 5 |
| Journal | DISEASES OF THE COLON & RECTUM |
| Volume | 41 |
| Issue number | 1 |
| Publication status | Published - Jan-1998 |
Keywords
- Crohn's disease, metastatic
- anti-tumor necrosis factor chimeric monoclonal antibody
- proctectomy
- perineal wound
- tumor necrosis factor
- FACTOR-ALPHA CA2
- RHEUMATOID-ARTHRITIS
- GRANULOMA-FORMATION