Tricin isolated from Allium atroviolaceum potentiated the effect of docetaxel on PC3 cell proliferation: Role of miR-21

Sorayya Ghasemi, Zahra Lorigooini*, JokoPriyanto Wibowo, Hossein Amini-khoei

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

For more effectiveness and overcoming the drug resistance Chemotherapy agents, the combination treatment is raised. Flavonoids with different anti-cancer effects are an appropriate choice as lead compounds. Over expressed MiR-21 in prostate cancer is associated with metastasis and drug resistance to chemotherapy with Docetaxel. In this study, the anticancer effect of 4 ', 5, 7-Trihydroxy-3 ', 5 '-dimethoxyflavone (Tricin) was investigated with Docetaxel on PC3 cell line. Tricin was initially isolated from the Allium atroviolaceum by column chromatography and recrystallization method. The chemical structure of isolate was elucidated by spectroscopic techniques. IC50 of Tricin and Docetaxel were assessed 117.5 +/- 4.4 mu M and 0.1 +/- 0.02 nM by MTT assay, respectively. Analysis of results indicates the synergistic effect of combination therapy on decreased proliferation. MiR-21 in treated cells with Tricin significantly decreased compared to control cells. So, Tricin can be effective in the reduction of metastasis and drug resistance of Docetaxel.

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Original languageEnglish
Pages (from-to)1828-1831
Number of pages4
JournalNatural Product Research
Volume33
Issue number12
DOIs
Publication statusPublished - 18-Jun-2019

Keywords

  • PC3
  • Tricin
  • docetaxel
  • proliferation
  • Allium atroviolaceum
  • miR-21
  • PROSTATE-CANCER

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