Abstract
The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described In satisfactory to good yields. N-Unsubstituted alpha-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 639-641 |
| Number of pages | 3 |
| Journal | Organic letters |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1-Feb-2013 |
Keywords
- 4-COMPONENT REACTION
- DERIVATIVES
- ACID
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CCDC 903083: Experimental Crystal Structure Determination
Zhao, T. (Contributor), Boltjes, A. (Contributor), Herdtweck, E. (Contributor) & Dömling, A. (Contributor), University of Groningen, 26-Sept-2012
DOI: 10.5517/ccz9qqp
Dataset
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CCDC 1950909: Experimental Crystal Structure Determination
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DOI: 10.5517/ccdc.csd.cc23h2k8
Dataset
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CCDC 1950908: Experimental Crystal Structure Determination
Zhao, T. (Contributor), Boltjes, A. (Contributor), Herdtweck, E. (Contributor) & Dömling, A. (Contributor), University of Groningen, 2-Sept-2019
DOI: 10.5517/ccdc.csd.cc23h2j7
Dataset