Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis

Ting Zhao, Andre Boltjes, Eberhardt Herdtweck, Alexander Doemling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Abstract

The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described In satisfactory to good yields. N-Unsubstituted alpha-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.

Original languageEnglish
Pages (from-to)639-641
Number of pages3
JournalOrganic letters
Volume15
Issue number3
DOIs
Publication statusPublished - 1-Feb-2013

Keywords

  • 4-COMPONENT REACTION
  • DERIVATIVES
  • ACID

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