Tumour-infiltrating lymphocytes: from prognosis to treatment selection

Koen Brummel, Anneke L. Eerkens, Marco de Bruyn, Hans W. Nijman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

92 Citations (Scopus)
104 Downloads (Pure)

Abstract

Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials.

Original languageEnglish
Pages (from-to)451–458
Number of pages8
JournalBritish Journal of Cancer
Volume128
Early online date23-Dec-2022
DOIs
Publication statusPublished - 2-Feb-2023

Fingerprint

Dive into the research topics of 'Tumour-infiltrating lymphocytes: from prognosis to treatment selection'. Together they form a unique fingerprint.

Cite this