TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample

Lotta-Katrin Pries, Clara Snijders, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Sinan Guloksuz, Jim van Os, Bart P. F. Rutten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically measured using experimental paradigms that assess neurocognitive processes such as salience attribution, sensitivity to social defeat and reward sensitivity. Here, we describe the TwinssCan, a longitudinal general population twin cohort, which comprises 1202 individuals (796 adolescent/young adult twins, 43 siblings and 363 parents) at baseline. The TwinssCan is part of the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia project and recruited from the East Flanders Prospective Twin Survey. The main objective of this project is to understand psychopathology by evaluating the contribution of genetic and nongenetic factors on subclinical expressions of dimensional phenotypes at a young age before the onset of disorder and their association with neurocognitive processes, such as salience attribution, sensitivity to social defeat and reward sensitivity.

Original languageEnglish
Article number1832427419000963
Pages (from-to)460-466
Number of pages7
JournalTwin research and human genetics
Volume22
Issue number6
DOIs
Publication statusPublished - Dec-2019

Keywords

  • Psychosis
  • depression
  • genetics
  • environment
  • salience attribution
  • social defeat
  • stress sensitivity
  • reward sensitivity
  • general population
  • twins
  • SUBCLINICAL PSYCHOSIS
  • CHILDHOOD TRAUMA
  • PEER EVALUATION
  • SCHIZOPHRENIA
  • EXPERIENCES
  • VALIDATION
  • DISORDER
  • SENSITIVITY
  • RELIABILITY
  • REACTIVITY

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