Type 2 Diabetes Mellitus and Clinicopathological Tumor Characteristics in Women Diagnosed with Breast Cancer: A Systematic Review and Meta-Analysis

Fan Zhang, Jing de Haan-Du, Grigory Sidorenkov*, Gijs W. D. Landman, Mathilde Jalving, Qingying Zhang, Geertruida H. de Bock

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
58 Downloads (Pure)

Abstract

Poor prognosis caused by type 2 diabetes mellitus (T2DM) in women with breast cancer is conferred, while the association between T2DM and breast tumor aggressiveness is still a matter of debate. This study aimed to clarify the differences in breast cancer characteristics, including stage, size, lymph node status, grade, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2), between patients with and without pre-existing T2DM. PubMed, Embase, and Web of Science were searched for studies from 1 January 2010 to 2 July 2021. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by using a random effects model. T2DM was significantly associated with tumor stages III/IV versus cancers in situ and stages I/II (pooled ORs (pOR), 95% CI: 1.19; 1.04–1.36, p = 0.012), tumor size >20 versus ≤20 mm (pOR, 95% CI: 1.18; 1.04–1.35, p = 0.013), and lymph node invasion versus no involvement (pOR, 95% CI: 1.26; 1.05–1.51, p = 0.013). These findings suggest that women with T2DM are at a higher risk of late-stage tumors, large tumor sizes, and invasive lymph nodes at breast cancer diagnosis.

Original languageEnglish
Article number4992
Number of pages23
JournalCancers
Volume13
Issue number19
DOIs
Publication statusPublished - 5-Oct-2021

Keywords

  • type 2 diabetes mellitus
  • breast cancer
  • tumor stage
  • tumor size
  • lymph node status
  • RISK
  • ASSOCIATION
  • OBESITY
  • METFORMIN
  • ESTROGEN
  • IMPACT
  • STAGE
  • MORTALITY
  • SUBTYPES
  • EXPRESSION

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