Ugi 4-CR synthesis of gamma- and delta-lactams providing new access to diverse enzyme interactions: a PDB analysis

Andre Boltjes, George P. Liao, Ting Zhao, Eberhardt Herdtweck, Alexander Doemling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

A three step synthesis of N-unsubstituted tetrazolo gamma- and delta-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted gamma- and delta-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.

Original languageEnglish
Pages (from-to)949-952
Number of pages4
JournalMedChemCommun
Volume5
Issue number7
DOIs
Publication statusPublished - 14-May-2014

Keywords

  • ENTEROVIRUS-71 INFECTION
  • PROMISING CANDIDATE
  • AMMONIA
  • RUPINTRIVIR
  • INHIBITORS
  • SURROGATE
  • PROTEASE
  • DESIGN

Cite this