Ugi-Smiles couplings of 4-substituted pyridine derivatives: A fast access to chloroquine analogues

Laurent El Kaïm, Laurence Grimaud*, Pravin Patil

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)


4-Hydroxy and mercapto pyridines were successfully tested in Ugi-Smiles couplings. Such multicomponent reactions applied to quinoline derivatives afford a very convenient and short synthesis of antimalarial analogues.

Original languageEnglish
Pages (from-to)476-478
Number of pages3
JournalOrganic letters
Issue number2
Publication statusPublished - 20-Jan-2012
Externally publishedYes


  • Antimalarials
  • Chloroquine
  • Molecular Structure
  • Pyridines
  • Time Factors

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