Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

Josep M. Anto*, Mariona Pinart, Muebeccel Akdis, Charles Auffray, Claus Bachert, Xavier Basagana, Kai-Hakon Carlsen, Stefano Guerra, Leena von Hertzen, Sabina Illi, Francine Kauffmann, Thomas Keil, James P. Kiley, Gerard H. Koppelman, Christian Lupinek, Fernando D. Martinez, Martijn C. Nawijn, Dirkje S. Postma, Valerie Siroux, Henriette A. SmitPeter J. Sterk, Jordi Sunyer, Rudolf Valenta, Sergio Valverde, Cezmi A. Akdis, Isabella Annesi-Maesano, Ferran Ballester, Marta Benet, Anne Cambon-Thomsen, Leda Chatzi, Jonathan Coquet, Pascal Demoly, Weiniu Gan, Judith Garcia-Aymerich, Elena Gimeno-Santos, Chantal Guihenneuc-Jouyaux, Tari Haahtela, Joachim Heinrich, Marie Herr, Cynthia Hohmann, Benedicte Jacquemin, Jocelyne Just, Marjan Kerkhof, Manolis Kogevinas, Marek L. Kowalski, Bart N. Lambrecht, Susanne Lau, Karin C. Lodrup Carlsen, Antoon J. M. van Oosterhout, Cisca Wijmenga, WHO Collaborating Ctr Asthma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

61 Citations (Scopus)


Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL. (J Allergy Clin Immunol 2012;129:943-54.)

Original languageEnglish
Pages (from-to)943-954.e4
Number of pages16
JournalJournal of Allergy and Clinical Immunology
Issue number4
Publication statusPublished - Apr-2012


  • Allergy
  • Mechanisms of the Development of Allergy
  • Seventh Framework Program
  • phenotypes
  • IgE
  • asthma

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