TY - JOUR
T1 - Understanding the complexity of IgE-related phenotypes from childhood to young adulthood
T2 - A Mechanisms of the Development of Allergy (MeDALL) Seminar
AU - Anto, Josep M.
AU - Pinart, Mariona
AU - Akdis, Muebeccel
AU - Auffray, Charles
AU - Bachert, Claus
AU - Basagana, Xavier
AU - Carlsen, Kai-Hakon
AU - Guerra, Stefano
AU - von Hertzen, Leena
AU - Illi, Sabina
AU - Kauffmann, Francine
AU - Keil, Thomas
AU - Kiley, James P.
AU - Koppelman, Gerard H.
AU - Lupinek, Christian
AU - Martinez, Fernando D.
AU - Nawijn, Martijn C.
AU - Postma, Dirkje S.
AU - Siroux, Valerie
AU - Smit, Henriette A.
AU - Sterk, Peter J.
AU - Sunyer, Jordi
AU - Valenta, Rudolf
AU - Valverde, Sergio
AU - Akdis, Cezmi A.
AU - Annesi-Maesano, Isabella
AU - Ballester, Ferran
AU - Benet, Marta
AU - Cambon-Thomsen, Anne
AU - Chatzi, Leda
AU - Coquet, Jonathan
AU - Demoly, Pascal
AU - Gan, Weiniu
AU - Garcia-Aymerich, Judith
AU - Gimeno-Santos, Elena
AU - Guihenneuc-Jouyaux, Chantal
AU - Haahtela, Tari
AU - Heinrich, Joachim
AU - Herr, Marie
AU - Hohmann, Cynthia
AU - Jacquemin, Benedicte
AU - Just, Jocelyne
AU - Kerkhof, Marjan
AU - Kogevinas, Manolis
AU - Kowalski, Marek L.
AU - Lambrecht, Bart N.
AU - Lau, Susanne
AU - Carlsen, Karin C. Lodrup
AU - van Oosterhout, Antoon J. M.
AU - Wijmenga, Cisca
AU - WHO Collaborating Ctr Asthma
PY - 2012/4
Y1 - 2012/4
N2 - Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL. (J Allergy Clin Immunol 2012;129:943-54.)
AB - Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL. (J Allergy Clin Immunol 2012;129:943-54.)
KW - Allergy
KW - Mechanisms of the Development of Allergy
KW - Seventh Framework Program
KW - phenotypes
KW - IgE
KW - asthma
KW - ASTHMA RESEARCH-PROGRAM
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - WORLD-HEALTH-ORGANIZATION
KW - T-REGULATORY-CELLS
KW - BIRTH-COHORT
KW - CLUSTER-ANALYSIS
KW - RUSSIAN KARELIA
KW - LUNG-FUNCTION
KW - BRONCHIAL HYPERRESPONSIVENESS
KW - DIAGNOSTIC GATEKEEPERS
U2 - 10.1016/j.jaci.2012.01.047
DO - 10.1016/j.jaci.2012.01.047
M3 - Article
SN - 0091-6749
VL - 129
SP - 943-954.e4
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 4
ER -