Unfavourable blood pressure and LDL-cholesterol levels in obese non-diabetic individuals

B. H. R. Wolffenbuttel*, S. N. Slagter, R. P. van Waateringe, A. P. van Beek, J. V. van Vliet-Ostaptchouk, M. M. van der Klauw

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Early diagnosis and treatment of high blood pressure (BP) and cholesterol is important to reduce cardiovascular risk. We compared BP and LDL-cholesterol (LDL-C) as well as the quality of treatment between obese subjects and normal weight and overweight individuals.

Methods: 87,648 participants of the Lifelines study were categorised according to obesity (normal weight/overweight/obesity) and age. Mean systolic BP and LDL-C were calculated depending on treatment, BMI, age and sex.

Results: In all age groups, except those aged 70-80 years, women had a significantly lower BP than men. Use of BP-lowering medication did not result in BP levels comparable with non-users, except in those aged 70-80 years. Despite medication, the BP was insufficiently controlled in 20-50% of participants. BP was significantly higher in obese vs. normal weight and overweight individuals of all ages, but most apparently in men younger than 50 years. Mean LDL-C varied between 2.5-3.0 mmol/l. Despite higher statin use, obese participants had a higher LDL-C than those with a normal weight. Statins abolished the age-dependent LDL-C increase. Many participants did not achieve target LDL-C <2.5 mmol/l. A small percentage of individuals treated with BP-lowering drugs were also using statins (overall 32% in men, 17% in women).

Conclusion: Obese individuals, especially men younger than 50, have a higher BP and LDL-C compared with those with overweight and a normal weight. Use of BP-lowering drugs did not revert the BP back to levels normal for the specific age and BMI group, whereas statins abolished the age-related increase in LDL-C. These data suggest that more attention is needed for active screening and treatment of cardiovascular risk factors.

Original languageEnglish
Pages (from-to)399-411
Number of pages13
JournalThe Netherlands Journal of Medicine
Volume75
Issue number9
Publication statusPublished - Nov-2017

Keywords

  • Blood pressure
  • lipids
  • obesity
  • epidemiology
  • treatment
  • BODY-MASS INDEX
  • RISK-FACTORS
  • CARDIOVASCULAR-DISEASE
  • HYPERTENSION MANAGEMENT
  • POPULATION COHORT
  • PRIMARY-CARE
  • PREVALENCE
  • PREVENTION
  • GUIDELINES
  • MORTALITY

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