Unmet Need in Renal Protection - Do We Need a More Comprehensive Approach?

Dick de Zeeuw*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

20 Citations (Scopus)

Abstract

Progressive renal function loss is still a threat to health despite the presence and use of renal protective drugs such as ACEi and ARB. This unmet need appears to be related to factors like a residual high blood pressure and residual albuminuria. Strategies that enhance the efficacy of RAAS blockade, such as increasing the dose of ACEi or ARB, combining ACEi and ARB, or new RAAS inhibitor drugs like the direct renin inhibitors may help us in improving renal protection. However, it is likely that renal disease progression is caused by multiple risk factors and that we will need multiple approaches to tackle this residual risk. Recent trials testing the effect of vitamin D receptor activators and the effect of statins indicate that drugs in these classes may become valuable extra tools (in addition to ACEi or ARB) to tackle the unmet need in renal protection. Copyright (C) 2011 S. Karger AG, Basel

Original languageEnglish
Title of host publicationHEMODIALYSIS: NEW METHODS AND FUTURE TECHNOLOGY
EditorsC Ronco, MH Rosner
Place of PublicationBASEL
PublisherKARGER
Pages157-160
Number of pages4
ISBN (Print)978-3-8055-9771-5
Publication statusPublished - 2011

Publication series

NameContributions to Nephrology
PublisherKARGER
Volume171
ISSN (Print)0302-5144

Keywords

  • CHRONIC KIDNEY-DISEASE
  • VITAMIN-D
  • CONTROLLED-TRIAL
  • DIABETIC-NEPHROPATHY
  • COMBINATION THERAPY
  • TYPE-2 DIABETES/
  • PARICALCITOL
  • LOSARTAN
  • RENOPROTECTION
  • INSUFFICIENCY

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