TY - JOUR
T1 - Unmet Needs and Perspectives in Oral Cancer Prevention
AU - Bouaoud, Jebrane
AU - Bossi, Paolo
AU - Elkabets, Moshe
AU - Schmitz, Sandra
AU - van Kempen, Léon C
AU - Martinez, Pierre
AU - Jagadeeshan, Sankar
AU - Breuskin, Ingrid
AU - Puppels, Gerwin J
AU - Hoffmann, Caroline
AU - Hunter, Keith D
AU - Simon, Christian
AU - Machiels, Jean-Pascal
AU - Grégoire, Vincent
AU - Bertolus, Chloé
AU - Brakenhoff, Ruud H
AU - Koljenović, Senada
AU - Saintigny, Pierre
PY - 2022/4/2
Y1 - 2022/4/2
N2 - Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.
AB - Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.
U2 - 10.3390/cancers14071815
DO - 10.3390/cancers14071815
M3 - Review article
C2 - 35406587
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 7
M1 - 1815
ER -