TY - JOUR
T1 - Unpuzzling COVID-19
T2 - Tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission
AU - Battagello, Daniella S
AU - Dragunas, Guilherme
AU - Klein, Marianne O
AU - Ayub, Ana L P
AU - Velloso, Fernando J
AU - Correa, Ricardo G
N1 - Funding Information:
This work was supported by the Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP, S?o Paulo Research Foundation) [grant numbers 2017/17998-5 (to M.O.K.), 2017/16549-2 (to G.D.), 2019/05641-0 (to A.L.P.A.)]; the Brazilian Coordena??o de Aperfei?oamento de Pessoal de Nivel Superior CAPES, Office for the Advancement of Higher Education [grant numbers PNPD/CAPES (to D.S.B.) and 1744709 (to A.L.P.A.)]; and the NIH (U.S.A.) [grant number NS107772 (to F.J.V.)].
Publisher Copyright:
© 2020 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
PY - 2020/8/1
Y1 - 2020/8/1
N2 - The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses - the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - discovered in December 2019 in the city of Wuhan (Hubei Province, China). Remarkably, COVID-19 has rapidly spread across all continents and turned into a public health emergency, which was ultimately declared as a pandemic by the World Health Organization (WHO) in early 2020. SARS-CoV-2 presents similar aspects to other members of the coronavirus family, mainly regarding its genome, protein structure and intracellular mechanisms, that may translate into mild (or even asymptomatic) to severe infectious conditions. Although the mechanistic features underlying the COVID-19 progression have not been fully clarified, current evidence have suggested that SARS-CoV-2 may primarily behave as other β-coronavirus members. To better understand the development and transmission of COVID-19, unveiling the signaling pathways that may be impacted by SARS-CoV-2 infection, at the molecular and cellular levels, is of crucial importance. In this review, we present the main aspects related to the origin, classification, etiology and clinical impact of SARS-CoV-2. Specifically, here we describe the potential mechanisms of cellular interaction and signaling pathways, elicited by functional receptors, in major targeted tissues/organs from the respiratory, gastrointestinal (GI), cardiovascular, renal, and nervous systems. Furthermore, the potential involvement of these signaling pathways in evoking the onset and progression of COVID-19 symptoms in these organ systems are presently discussed. A brief description of future perspectives related to potential COVID-19 treatments is also highlighted.
AB - The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses - the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - discovered in December 2019 in the city of Wuhan (Hubei Province, China). Remarkably, COVID-19 has rapidly spread across all continents and turned into a public health emergency, which was ultimately declared as a pandemic by the World Health Organization (WHO) in early 2020. SARS-CoV-2 presents similar aspects to other members of the coronavirus family, mainly regarding its genome, protein structure and intracellular mechanisms, that may translate into mild (or even asymptomatic) to severe infectious conditions. Although the mechanistic features underlying the COVID-19 progression have not been fully clarified, current evidence have suggested that SARS-CoV-2 may primarily behave as other β-coronavirus members. To better understand the development and transmission of COVID-19, unveiling the signaling pathways that may be impacted by SARS-CoV-2 infection, at the molecular and cellular levels, is of crucial importance. In this review, we present the main aspects related to the origin, classification, etiology and clinical impact of SARS-CoV-2. Specifically, here we describe the potential mechanisms of cellular interaction and signaling pathways, elicited by functional receptors, in major targeted tissues/organs from the respiratory, gastrointestinal (GI), cardiovascular, renal, and nervous systems. Furthermore, the potential involvement of these signaling pathways in evoking the onset and progression of COVID-19 symptoms in these organ systems are presently discussed. A brief description of future perspectives related to potential COVID-19 treatments is also highlighted.
U2 - 10.1042/CS20200904
DO - 10.1042/CS20200904
M3 - Review article
C2 - 32820801
SN - 0143-5221
VL - 134
SP - 2137
EP - 2160
JO - Clinical Science
JF - Clinical Science
IS - 16
ER -