TY - JOUR
T1 - Unraveling the role of computed tomography derived body composition metrics on anastomotic leakages rates in rectal cancer surgery
T2 - A protocol for a systematic review and meta-analysis
AU - Broekman, Mark
AU - Genders, Charlotte M S
AU - Geitenbeek, Ritchie T J
AU - Havenga, Klaas
AU - Kruijff, Schelto
AU - Klaase, Joost M
AU - Viddeleer, Alain R
AU - Consten, Esther C J
N1 - Copyright: © 2024 Broekman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2024
Y1 - 2024
N2 - INTRODUCTION: Anastomotic leakage is a major concern following total mesorectal excision for rectal cancer, affecting oncological outcomes, morbidity an treatment costs. Body composition has been suggested to influence anastomotic leakage rates. However, literature on how body composition impact anastomotic leakage rates is conflicting. This systematic review aims to evaluate the role of computed tomography derived body composition metrics on anastomotic leakage rates in rectal cancer patients.METHODS: Databases PubMed/MEDLINE, Cochrane Library, web of science, and EMBASE, will be systematically searched for papers from January 2010 onwards. Study selection, data collection and quality assessment will be independently performed by three research fellows. Outcomes described in three or more studies will be included in the meta-analysis. The Q-test and I2 statistic will be used to assess statistical heterogeneity between studies. Publication bias will be examined by visual inspection of funnel plots and quantified by Egger's test. Sensitivity analyses will be conducted to examine the robustness of the meta-analysis. Reporting of the findings will be in line with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.CONCLUSIONS: This systematic review will synthesize the current evidence and will identify knowledge gaps. Results of the systematic review will aid health care professional in pre-operative decision making and will be distributed through a peer-reviewed publication and presentation of results at international meetings.TRIAL REGISTRATION: PROSPERO protocol number: CRD42023471537.
AB - INTRODUCTION: Anastomotic leakage is a major concern following total mesorectal excision for rectal cancer, affecting oncological outcomes, morbidity an treatment costs. Body composition has been suggested to influence anastomotic leakage rates. However, literature on how body composition impact anastomotic leakage rates is conflicting. This systematic review aims to evaluate the role of computed tomography derived body composition metrics on anastomotic leakage rates in rectal cancer patients.METHODS: Databases PubMed/MEDLINE, Cochrane Library, web of science, and EMBASE, will be systematically searched for papers from January 2010 onwards. Study selection, data collection and quality assessment will be independently performed by three research fellows. Outcomes described in three or more studies will be included in the meta-analysis. The Q-test and I2 statistic will be used to assess statistical heterogeneity between studies. Publication bias will be examined by visual inspection of funnel plots and quantified by Egger's test. Sensitivity analyses will be conducted to examine the robustness of the meta-analysis. Reporting of the findings will be in line with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.CONCLUSIONS: This systematic review will synthesize the current evidence and will identify knowledge gaps. Results of the systematic review will aid health care professional in pre-operative decision making and will be distributed through a peer-reviewed publication and presentation of results at international meetings.TRIAL REGISTRATION: PROSPERO protocol number: CRD42023471537.
KW - Humans
KW - Anastomotic Leak/epidemiology
KW - Body Composition
KW - Meta-Analysis as Topic
KW - Rectal Neoplasms/surgery
KW - Systematic Reviews as Topic
KW - Tomography, X-Ray Computed
U2 - 10.1371/journal.pone.0307606
DO - 10.1371/journal.pone.0307606
M3 - Article
C2 - 39046997
SN - 1932-6203
VL - 19
JO - PLoS ONE
JF - PLoS ONE
IS - 7
M1 - e0307606
ER -