Unravelling the complexities of chromosomal instability in cancer: exploring molecular pathways and potential therapeutic targets

This thesis provides a thorough investigation of the relationship between CIN, SAC inhibition, EVs, and their impact on cancer progression, specifically focusing on TNBC. The study aims to dissect the intricate dynamics of CIN and SAC inhibition in TNBC, with a particular focus on the molecular roles of HDAC4, CDC20, and EFEMP1. We explore HDAC4's influence on cell cycle regulation and tumour growth, CDC20's contribution to SAC inhibitor sensitivity, and EFEMP1's role in mediating tumour metastasis through EVs. Our work contributes to a better understanding of TNBC's aggressive nature and identifies potential therapeutic interventions tailored to combat this challenging cancer subtype effectively.