Uric acid in multiple sclerosis

M Koch, J De Keyser*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    31 Citations (Scopus)

    Abstract

    Peroxynitrite, a reactive oxidant formed by the reaction of nitric oxide with superoxide at sites of inflammation in multiple sclerosis (MS), is capable of damaging tissues and cells. Uric acid, a natural scavenger of peroxynitrite, reduces inflammatory demyelination in experimental allergic encephalomyelitis. Some studies reported lower serum levels of uric acid in MS patients compared with controls, whereas other studies found no difference. A critical appraisal of these studies favors the view that reduced uric acid in MS is secondary to its peroxynitrite scavenging activity during inflammatory disease activity, rather than a primary deficiency. Serum uric acid levels could be used as a biomarker for monitoring disease activity in MS. Therapeutic strategies aimed at raising serum uric acid levels may have a glial/neuroprotective effect on MS patients.

    Original languageEnglish
    Pages (from-to)316-319
    Number of pages4
    JournalNeurological Research
    Volume28
    Issue number3
    DOIs
    Publication statusPublished - Apr-2006

    Keywords

    • multiple sclerosis
    • uric acid
    • peroxynitrite
    • oxidative stress
    • reactive nitrogen species
    • EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
    • CENTRAL-NERVOUS-SYSTEM
    • INFLAMMATORY CELL INVASION
    • NITRIC-OXIDE SYNTHASE
    • PEROXYNITRITE SCAVENGER
    • PROTECTION
    • THERAPY
    • INACTIVATION
    • ACTIVATION
    • RECEPTORS

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