Urinary Connective Tissue Growth Factor Is Associated with Human Renal Allograft Fibrogenesis

Christoph Metalidis, Stefan H. van Vuuren, Roel Broekhuizen, Evelyne Lerut, Maarten Naesens, Stephan J. L. Bakker, Jack F. M. Wetzels, Roel Goldschmeding, Dirk R. J. Kuypers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Background. Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model.

Methods. We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during the first 2 years after transplantation. Histologic and biochemical data were collected from 315 kidney transplant recipients enrolled in a protocol biopsy-based clinical program.

Results. At 3, 12, and 24 months after transplantation, CTGFu levels were independently associated with the degree of interstitial fibrosis in protocol biopsies, scored according to the revised 1997 Banff criteria. In a subgroup of 164 patients with pristine biopsies at 3 months, higher CTGFu levels at 3 months were associated with moderate and severe interstitial fibrosis developed at 24 months after transplantation.

Conclusions. As it is readily quantifiable in urine, a role for CTGFu as a noninvasive candidate biomarker and predictor of human renal allograft fibrogenesis deserves further study.

Original languageEnglish
Pages (from-to)494-500
Number of pages7
JournalTransplantation
Volume96
Issue number5
DOIs
Publication statusPublished - 15-Sep-2013

Keywords

  • Kidney transplantation
  • Chronic allograft injury
  • Fibrosis
  • Connective tissue growth factor
  • FACTOR GENE-EXPRESSION
  • FACTOR CTGF/CCN2
  • FACTOR EXCRETION
  • FIBROSIS
  • CELLS
  • CLASSIFICATION
  • PROLIFERATION
  • NEPHROPATHY
  • INHIBITION
  • REJECTION

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