Urinary Connective Tissue Growth Factor Is Associated with Human Renal Allograft Fibrogenesis

Christoph Metalidis; Stefan H. van Vuuren; Roel Broekhuizen; Evelyne Lerut; Maarten Naesens; Stephan J. L. Bakker; Jack F. M. Wetzels; Roel Goldschmeding; Dirk R. J. Kuypers

doi:10.1097/TP.0b013e31829b07e1

Urinary Connective Tissue Growth Factor Is Associated with Human Renal Allograft Fibrogenesis

Christoph Metalidis, Stefan H. van Vuuren, Roel Broekhuizen, Evelyne Lerut, Maarten Naesens, Stephan J. L. Bakker, Jack F. M. Wetzels, Roel Goldschmeding, Dirk R. J. Kuypers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Background. Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model.

Methods. We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during the first 2 years after transplantation. Histologic and biochemical data were collected from 315 kidney transplant recipients enrolled in a protocol biopsy-based clinical program.

Results. At 3, 12, and 24 months after transplantation, CTGFu levels were independently associated with the degree of interstitial fibrosis in protocol biopsies, scored according to the revised 1997 Banff criteria. In a subgroup of 164 patients with pristine biopsies at 3 months, higher CTGFu levels at 3 months were associated with moderate and severe interstitial fibrosis developed at 24 months after transplantation.

Conclusions. As it is readily quantifiable in urine, a role for CTGFu as a noninvasive candidate biomarker and predictor of human renal allograft fibrogenesis deserves further study.

Original language	English
Pages (from-to)	494-500
Number of pages	7
Journal	Transplantation
Volume	96
Issue number	5
DOIs	https://doi.org/10.1097/TP.0b013e31829b07e1
Publication status	Published - 15-Sept-2013

Keywords

Kidney transplantation
Chronic allograft injury
Fibrosis
Connective tissue growth factor
FACTOR GENE-EXPRESSION
FACTOR CTGF/CCN2
FACTOR EXCRETION
FIBROSIS
CELLS
CLASSIFICATION
PROLIFERATION
NEPHROPATHY
INHIBITION
REJECTION

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@article{93b8f331b01a4747b8a95002bacd7968,

title = "Urinary Connective Tissue Growth Factor Is Associated with Human Renal Allograft Fibrogenesis",

abstract = "Background. Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model.Methods. We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during the first 2 years after transplantation. Histologic and biochemical data were collected from 315 kidney transplant recipients enrolled in a protocol biopsy-based clinical program.Results. At 3, 12, and 24 months after transplantation, CTGFu levels were independently associated with the degree of interstitial fibrosis in protocol biopsies, scored according to the revised 1997 Banff criteria. In a subgroup of 164 patients with pristine biopsies at 3 months, higher CTGFu levels at 3 months were associated with moderate and severe interstitial fibrosis developed at 24 months after transplantation.Conclusions. As it is readily quantifiable in urine, a role for CTGFu as a noninvasive candidate biomarker and predictor of human renal allograft fibrogenesis deserves further study.",

keywords = "Kidney transplantation, Chronic allograft injury, Fibrosis, Connective tissue growth factor, FACTOR GENE-EXPRESSION, FACTOR CTGF/CCN2, FACTOR EXCRETION, FIBROSIS, CELLS, CLASSIFICATION, PROLIFERATION, NEPHROPATHY, INHIBITION, REJECTION",

author = "Christoph Metalidis and {van Vuuren}, {Stefan H.} and Roel Broekhuizen and Evelyne Lerut and Maarten Naesens and Bakker, {Stephan J. L.} and Wetzels, {Jack F. M.} and Roel Goldschmeding and Kuypers, {Dirk R. J.}",

year = "2013",

month = sep,

day = "15",

doi = "10.1097/TP.0b013e31829b07e1",

language = "English",

volume = "96",

pages = "494--500",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "5",

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TY - JOUR

T1 - Urinary Connective Tissue Growth Factor Is Associated with Human Renal Allograft Fibrogenesis

AU - Metalidis, Christoph

AU - van Vuuren, Stefan H.

AU - Broekhuizen, Roel

AU - Lerut, Evelyne

AU - Naesens, Maarten

AU - Bakker, Stephan J. L.

AU - Wetzels, Jack F. M.

AU - Goldschmeding, Roel

AU - Kuypers, Dirk R. J.

PY - 2013/9/15

Y1 - 2013/9/15

N2 - Background. Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model.Methods. We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during the first 2 years after transplantation. Histologic and biochemical data were collected from 315 kidney transplant recipients enrolled in a protocol biopsy-based clinical program.Results. At 3, 12, and 24 months after transplantation, CTGFu levels were independently associated with the degree of interstitial fibrosis in protocol biopsies, scored according to the revised 1997 Banff criteria. In a subgroup of 164 patients with pristine biopsies at 3 months, higher CTGFu levels at 3 months were associated with moderate and severe interstitial fibrosis developed at 24 months after transplantation.Conclusions. As it is readily quantifiable in urine, a role for CTGFu as a noninvasive candidate biomarker and predictor of human renal allograft fibrogenesis deserves further study.

AB - Background. Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model.Methods. We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during the first 2 years after transplantation. Histologic and biochemical data were collected from 315 kidney transplant recipients enrolled in a protocol biopsy-based clinical program.Results. At 3, 12, and 24 months after transplantation, CTGFu levels were independently associated with the degree of interstitial fibrosis in protocol biopsies, scored according to the revised 1997 Banff criteria. In a subgroup of 164 patients with pristine biopsies at 3 months, higher CTGFu levels at 3 months were associated with moderate and severe interstitial fibrosis developed at 24 months after transplantation.Conclusions. As it is readily quantifiable in urine, a role for CTGFu as a noninvasive candidate biomarker and predictor of human renal allograft fibrogenesis deserves further study.

KW - Kidney transplantation

KW - Chronic allograft injury

KW - Fibrosis

KW - Connective tissue growth factor

KW - FACTOR GENE-EXPRESSION

KW - FACTOR CTGF/CCN2

KW - FACTOR EXCRETION

KW - FIBROSIS

KW - CELLS

KW - CLASSIFICATION

KW - PROLIFERATION

KW - NEPHROPATHY

KW - INHIBITION

KW - REJECTION

U2 - 10.1097/TP.0b013e31829b07e1

DO - 10.1097/TP.0b013e31829b07e1

M3 - Article

SN - 0041-1337

VL - 96

SP - 494

EP - 500

JO - Transplantation

JF - Transplantation

IS - 5

ER -

Urinary Connective Tissue Growth Factor Is Associated with Human Renal Allograft Fibrogenesis

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