Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction

Koen W Streng, Hans L Hillege, Jozine M Ter Maaten, Dirk J van Veldhuisen, Kenneth Dickstein, Nilesh J Samani, Leong L Ng, Marco Metra, Gerasimos S Filippatos, Piotr Ponikowski, Faiez Zannad, Stefan D Anker, Peter van der Meer, Chim C Lang, Adriaan A Voors*, Kevin Damman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
24 Downloads (Pure)

Abstract

BACKGROUND: Recent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting different nephron segments in heart failure patients.

METHODS: In 2070, in chronic heart failure patients, we measured several established and upcoming urinary markers reflecting different nephron segments.

RESULTS: Mean age was 70 ± 12 years, 74% was male and 81% (n = 1677) had HFrEF. Mean estimated glomerular filtration rate (eGFR) was lower in patients with HFpEF (56 ± 23 versus 63 ± 23 ml/min/1.73 m 2, P = 0.001). Patients with HFpEF had significantly higher values of NGAL (58.1 [24.0-124.8] versus 28.1 [14.6-66.9] μg/gCr, P < 0.001) and KIM-1 (2.28 [1.49-4.37] versus 1.79 [0.85-3.49] μg/gCr, P = 0.001). These differences were more pronounced in patients with an eGFR > 60 ml/min/1.73m 2.

CONCLUSIONS: HFpEF patients showed more evidence of tubular damage and/or dysfunction compared with HFrEF patients, in particular when glomerular function was preserved.

Original languageEnglish
Pages (from-to)3–12
Number of pages10
JournalJournal of cardiovascular translational research
Volume17
Early online date16-Feb-2023
DOIs
Publication statusPublished - Jun-2024

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