Use of real-world evidence in pharmacoeconomic analysis: illustrations in The Netherlands and China

Yunyu Huang

    Research output: ThesisThesis fully internal (DIV)

    1335 Downloads (Pure)

    Abstract

    The main objective of the thesis is to assess the added value of use of observational data in pharmacoeconomic (PE) evaluations. Five sub-aims were addressed in the thesis:
    1) a systematic literature review summarized results evidencing the cost-saving potentials of renin-angiotensin-aldosterone system (RAAS) inhibitors, including angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARBs), in type 2 diabetes (T2D) patients with nephropathy compared with conventional therapy excluding a RAAS inhibitor;
    2) a general framework was developed to illustrate the problems and solutions of data quality assessment and preprocessing, based on the ‘fit-for-use’ concept;
    3) a comparative effectiveness study compared the effectiveness of ACE inhibitors vs. ARBs for protecting T2D patients from renal function decline in a real-world setting, the value of observational data in outcomes research studies was assessed;
    4) a real-world study described the changes of diabetes cost in Chinese patients using electronic claims data, and the value of observational data in health economics studies was assessed;
    5) a cost-effectiveness analysis of RAAS inhibitors (ACE inhibitors and ARBs) vs. other active anti-hypertensive agents and no anti-hypertensive treatment in patients with T2D and nephropathy in China was performed from a healthcare payer perspective, and a budget impact analysis was conducted alongside the PE evaluation to analyze the budget changes of Chinese urban employee basic medical insurance (UEBMI) when different strategies of medication use are applied; the use of observational data in PE evaluations was assessed.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Haaijer-Ruskamp, Floor, Supervisor
    • Postma, Maarten, Supervisor
    • Vemer, Pepijn, Co-supervisor
    Award date16-Sept-2019
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-1870-4
    Electronic ISBNs978-94-034-1869-8
    DOIs
    Publication statusPublished - 2019

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