Using a novel concept to measure outcomes in solid organ recipients provided promising results

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: Efforts to evaluate the health of solid organ transplant recipients are hampered by the lack of adequate patient-reported outcome measures (PROMs) targeting this group. We developed the Transplant ePROM (TXP), which is based on a novel measurement model and administered through a mobile application to fill this gap. The main objective of this article is to elucidate how we derived the weights for different items, and to report initial empirical results. Study design and setting: The nine health items in the TXP were fatigue, skin, worry, self-reliance, activities, weight, sexuality, stooling, and memory. Via an online survey solid organ recipient participating in the TransplantLines Biobank and Cohort study (NCT03272841) were asked to describe and then compare their own health state with six other health states. Coefficients for item levels were obtained using a conditional logit model. Results: A total of 232 solid organ transplant recipients (mean age: 54 years) participated. The majority (106) were kidney recipients, followed by lung, liver, and heart recipients. Fatigue was the most frequent complaint (54%). The strongest negative coefficients were found for activities and worry, followed by self-reliance and memory. Conclusion: A set of coefficients and values were developed for TXP. The TXP score approximated an optimal health state for the majority of respondents and recipients of different organs reported comparable health states. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Original languageEnglish
Pages (from-to)96-106
Number of pages11
JournalJournal of Clinical Epidemiology
Volume139
DOIs
Publication statusPublished - Nov-2021

Keywords

  • Health-related quality of life
  • Health outcome
  • Patient-reported outcome measure
  • Preference based
  • Transplantation
  • TXP
  • QUALITY-OF-LIFE
  • TRANSPLANT RECIPIENTS
  • RESPONSE SHIFT
  • MINUS 2
  • FATIGUE
  • LIVER
  • CAPACITY
  • KIDNEY
  • PLUS

Cite this