Utilization of in vivo ultrafiltration in biomedical research and clinical applications

G Leegsma-Vogt*, E Janle, [No Value] Ash, K Venema, J Korf

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    47 Citations (Scopus)

    Abstract

    Ultrafiltration (UF) is a filtrate selection method with a wide range of biomedical and clinical applications, including detoxification of blood in hemodialysis and peritoneal dialysis. New is, however, the use of UF as a convenient in vivo sampling method that, for example, has been used in diabetics. Ultrafiltration avoids complicated and time-consuming recovery calculations that are necessary when using in vivo microdialysis, as recoveries of low molecular weight molecules are near 100%. The subcutaneously or intravenously placed UF probes have been studied for off-line sample analysis and for continuous on-line monitoring, in a wide variety of species, including dogs, rats, pigs and humans.

    This review discusses the potential of in vivo UF as a continuous tissue sampling technique in clinical research areas, and in several major biomedical applications including glucose and lactate monitoring and drug kinetic studies. (C) 2003 Elsevier Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)2005-2018
    Number of pages14
    JournalLife Sciences
    Volume73
    Issue number16
    DOIs
    Publication statusPublished - 5-Sep-2003

    Keywords

    • ultrafiltration
    • in vivo
    • glucose
    • lactate
    • drug kinetics
    • off-line
    • on-line
    • CAPILLARY FILTRATE COLLECTOR
    • HUMAN SKELETAL-MUSCLE
    • INTRAVENOUS MICRODIALYSIS
    • INVIVO MICRODIALYSIS
    • SAMPLING PROBES
    • ADIPOSE-TISSUE
    • GLUCOSE
    • LACTATE
    • RATS
    • HEMODIALYSIS

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