Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions

V A B van den Bogaard; B D P Ta; A van der Schaaf; A B Bouma; A M H Middag; E J Bantema-Joppe; L.V. van Dijk; F B J van Dijk-Peters; L A W Marteijn; G H de Bock; J G M Burgerhof; J A Gietema; J A Langendijk; J H Maduro; A P G Crijns

doi:10.1016/j.ijrobp.2016.06.027

Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions

V A B van den Bogaard, B D P Ta, A van der Schaaf, A B Bouma, A M H Middag, E J Bantema-Joppe, L.V. van Dijk, F B J van Dijk-Peters, L A W Marteijn, G H de Bock, J G M Burgerhof, J A Gietema, J A Langendijk, J H Maduro, A P G Crijns

Research output: Contribution to journal › Meeting Abstract › Academic

Abstract

P Z 0.0016). Within the 100 genes, enriched biological functions relate to clusters of genes governing protein degradation, RNA processing, apoptosis, the cell cycle, ATP synthesis, and a large cluster of genes relating to protein localization. Conclusion: We have identified three novel intrinsic subtypes of prostate cancer in the largest study of its kind, and validated our findings across sequencing platforms, storage methods, and within both retrospective and prospective cohorts. In defining unique biological clusters of disease, the PC100 represents a step towards personalization of prostate cancer care. Future work will focus on validating the predictive capacity of these subtypes to therapy such as radiation therapy.

Original language	English
Pages (from-to)	S4-S5
Number of pages	2
Journal	International Journal of Radiation Oncology Biology Physics
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/j.ijrobp.2016.06.027
Publication status	Published - 1-Oct-2016
Event	58th Annual Meeting of the American-Society-for-Radiation-Oncology - Boston, United States Duration: 25-Sept-2016 → 28-Sept-2016

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van den Bogaard, V. A. B., Ta, B. D. P., van der Schaaf, A., Bouma, A. B., Middag, A. M. H., Bantema-Joppe, E. J., van Dijk, L. V., van Dijk-Peters, F. B. J., Marteijn, L. A. W., de Bock, G. H., Burgerhof, J. G. M., Gietema, J. A., Langendijk, J. A., Maduro, J. H., & Crijns, A. P. G. (2016). Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions. International Journal of Radiation Oncology Biology Physics, 96(2), S4-S5. https://doi.org/10.1016/j.ijrobp.2016.06.027

@article{3d6d39c7b6d44a82806fafbe7ed106ff,

title = "Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions",

abstract = "P Z 0.0016). Within the 100 genes, enriched biological functions relate to clusters of genes governing protein degradation, RNA processing, apoptosis, the cell cycle, ATP synthesis, and a large cluster of genes relating to protein localization. Conclusion: We have identified three novel intrinsic subtypes of prostate cancer in the largest study of its kind, and validated our findings across sequencing platforms, storage methods, and within both retrospective and prospective cohorts. In defining unique biological clusters of disease, the PC100 represents a step towards personalization of prostate cancer care. Future work will focus on validating the predictive capacity of these subtypes to therapy such as radiation therapy.",

author = "{van den Bogaard}, {V A B} and Ta, {B D P} and {van der Schaaf}, A and Bouma, {A B} and Middag, {A M H} and Bantema-Joppe, {E J} and {van Dijk}, L.V. and {van Dijk-Peters}, {F B J} and Marteijn, {L A W} and {de Bock}, {G H} and Burgerhof, {J G M} and Gietema, {J A} and Langendijk, {J A} and Maduro, {J H} and Crijns, {A P G}",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.ijrobp.2016.06.027",

language = "English",

volume = "96",

pages = "S4--S5",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "ELSEVIER SCIENCE INC",

number = "2",

note = "58th Annual Meeting of the American-Society-for-Radiation-Oncology ; Conference date: 25-09-2016 Through 28-09-2016",

}

van den Bogaard, VAB, Ta, BDP, van der Schaaf, A, Bouma, AB, Middag, AMH, Bantema-Joppe, EJ, van Dijk, LV, van Dijk-Peters, FBJ, Marteijn, LAW, de Bock, GH, Burgerhof, JGM, Gietema, JA , Langendijk, JA , Maduro, JH & Crijns, APG 2016, 'Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions', International Journal of Radiation Oncology Biology Physics, vol. 96, no. 2, pp. S4-S5. https://doi.org/10.1016/j.ijrobp.2016.06.027

Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions. / van den Bogaard, V A B; Ta, B D P; van der Schaaf, A et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 96, No. 2, 01.10.2016, p. S4-S5.

Research output: Contribution to journal › Meeting Abstract › Academic

TY - JOUR

T1 - Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions

AU - van den Bogaard, V A B

AU - Ta, B D P

AU - van der Schaaf, A

AU - Bouma, A B

AU - Middag, A M H

AU - Bantema-Joppe, E J

AU - van Dijk, L.V.

AU - van Dijk-Peters, F B J

AU - Marteijn, L A W

AU - de Bock, G H

AU - Burgerhof, J G M

AU - Gietema, J A

AU - Langendijk, J A

AU - Maduro, J H

AU - Crijns, A P G

PY - 2016/10/1

Y1 - 2016/10/1

N2 - P Z 0.0016). Within the 100 genes, enriched biological functions relate to clusters of genes governing protein degradation, RNA processing, apoptosis, the cell cycle, ATP synthesis, and a large cluster of genes relating to protein localization. Conclusion: We have identified three novel intrinsic subtypes of prostate cancer in the largest study of its kind, and validated our findings across sequencing platforms, storage methods, and within both retrospective and prospective cohorts. In defining unique biological clusters of disease, the PC100 represents a step towards personalization of prostate cancer care. Future work will focus on validating the predictive capacity of these subtypes to therapy such as radiation therapy.

AB - P Z 0.0016). Within the 100 genes, enriched biological functions relate to clusters of genes governing protein degradation, RNA processing, apoptosis, the cell cycle, ATP synthesis, and a large cluster of genes relating to protein localization. Conclusion: We have identified three novel intrinsic subtypes of prostate cancer in the largest study of its kind, and validated our findings across sequencing platforms, storage methods, and within both retrospective and prospective cohorts. In defining unique biological clusters of disease, the PC100 represents a step towards personalization of prostate cancer care. Future work will focus on validating the predictive capacity of these subtypes to therapy such as radiation therapy.

U2 - 10.1016/j.ijrobp.2016.06.027

DO - 10.1016/j.ijrobp.2016.06.027

M3 - Meeting Abstract

C2 - 27675920

SN - 0360-3016

VL - 96

SP - S4-S5

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 2

T2 - 58th Annual Meeting of the American-Society-for-Radiation-Oncology

Y2 - 25 September 2016 through 28 September 2016

ER -

Validation and Optimization of a Cardiac NTCP Model for Breast Cancer Patients Based on Cardiac Substructures and 3-dimensional Dose Distributions

Abstract

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