Validation of the Pancreas Donor Risk Index for use in a UK population

Shruti Mittal; Fang Jann Lee; Lisa Bradbury; David Collett; Srikanth Reddy; Sanjay Sinha; Edward Sharples; Rutger J. Ploeg; Peter J. Friend; Anil Vaidya

doi:10.1111/tri.12563

Validation of the Pancreas Donor Risk Index for use in a UK population

Shruti Mittal^*, Fang Jann Lee, Lisa Bradbury, David Collett, Srikanth Reddy, Sanjay Sinha, Edward Sharples, Rutger J. Ploeg, Peter J. Friend, Anil Vaidya

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P=0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.

Original language	English
Pages (from-to)	1028-1033
Number of pages	6
Journal	Transplant International
Volume	28
Issue number	9
DOIs	https://doi.org/10.1111/tri.12563
Publication status	Published - Sept-2015
Externally published	Yes

Keywords

pancreas transplant
graft survival
risk
predictor
GRAFT-SURVIVAL
KIDNEY TRANSPLANTATION
SUITABILITY SCORE
OUTCOMES
QUALITY

Access to Document

10.1111/tri.12563

Handle.net

Persistent link

Cite this

@article{2b6c8b9427e544cbba160e8a42febc2e,

title = "Validation of the Pancreas Donor Risk Index for use in a UK population",

abstract = "Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P=0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.",

keywords = "pancreas transplant, graft survival, risk, predictor, GRAFT-SURVIVAL, KIDNEY TRANSPLANTATION, SUITABILITY SCORE, OUTCOMES, QUALITY",

author = "Shruti Mittal and Lee, {Fang Jann} and Lisa Bradbury and David Collett and Srikanth Reddy and Sanjay Sinha and Edward Sharples and Ploeg, {Rutger J.} and Friend, {Peter J.} and Anil Vaidya",

year = "2015",

month = sep,

doi = "10.1111/tri.12563",

language = "English",

volume = "28",

pages = "1028--1033",

journal = "Transplant International",

issn = "0934-0874",

publisher = "Wiley",

number = "9",

}

TY - JOUR

T1 - Validation of the Pancreas Donor Risk Index for use in a UK population

AU - Mittal, Shruti

AU - Lee, Fang Jann

AU - Bradbury, Lisa

AU - Collett, David

AU - Reddy, Srikanth

AU - Sinha, Sanjay

AU - Sharples, Edward

AU - Ploeg, Rutger J.

AU - Friend, Peter J.

AU - Vaidya, Anil

PY - 2015/9

Y1 - 2015/9

N2 - Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P=0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.

AB - Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P=0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.

KW - pancreas transplant

KW - graft survival

KW - risk

KW - predictor

KW - GRAFT-SURVIVAL

KW - KIDNEY TRANSPLANTATION

KW - SUITABILITY SCORE

KW - OUTCOMES

KW - QUALITY

U2 - 10.1111/tri.12563

DO - 10.1111/tri.12563

M3 - Article

SN - 0934-0874

VL - 28

SP - 1028

EP - 1033

JO - Transplant International

JF - Transplant International

IS - 9

ER -