Validation of the Pancreas Donor Risk Index for use in a UK population

Shruti Mittal*, Fang Jann Lee, Lisa Bradbury, David Collett, Srikanth Reddy, Sanjay Sinha, Edward Sharples, Rutger J. Ploeg, Peter J. Friend, Anil Vaidya

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P=0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.

Original languageEnglish
Pages (from-to)1028-1033
Number of pages6
JournalTransplant International
Volume28
Issue number9
DOIs
Publication statusPublished - Sept-2015
Externally publishedYes

Keywords

  • pancreas transplant
  • graft survival
  • risk
  • predictor
  • GRAFT-SURVIVAL
  • KIDNEY TRANSPLANTATION
  • SUITABILITY SCORE
  • OUTCOMES
  • QUALITY

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