Vascular benefits of angiotensin receptor blockers

Adriaan A. Voors*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

There is convincing evidence that angiotensin II, through activation of the angiotensin II type 1 (AT1) receptor, is involved in the atherosclerotic process. Similarly, angiotensin receptor blockers decrease vascular inflammation, hypertrophy and thrombosis, which are the key components of the progression of atherosclerosis. In addition, in several animal models, angiotensin receptor blockade was able to inhibit atherosclerosis. However, the effects of angiotensin receptor blockers on clinical outcome in cardiovascular patients remains to be established. Contradictory results have been found on the reduction of the risk on myocardial infarctions and in-stent restenosis, although there is solid evidence for cerebroprotective effects of these receptor blockers. These differences may be related to the role of the AT2 receptor. This review discusses the role of angiotensin II and angiotensin receptor blockers in the atherosclerotic process and its translation into clinical practice.

Original languageEnglish
Pages (from-to)987-997
Number of pages11
JournalExpert opinion on investigational drugs
Volume16
Issue number7
DOIs
Publication statusPublished - Jul-2007

Keywords

  • angiotensin
  • atherosclerosis
  • vascular
  • CONVERTING ENZYME-INHIBITION
  • SMOOTH-MUSCLE-CELLS
  • SPONTANEOUSLY HYPERTENSIVE-RATS
  • CORONARY-ARTERY-DISEASE
  • UNILATERAL CAROTID LIGATION
  • LOW-DENSITY-LIPOPROTEIN
  • FACTOR-KAPPA-B
  • MYOCARDIAL-INFARCTION
  • ENDOTHELIAL-CELLS
  • MATRIX METALLOPROTEINASE-1

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