Vascular events after liver transplantation: a long-term follow-up study

Maarten A. J. P. Borg, Egbert-Jan van der Wouden*, Wim J. Sluiter, Maarten J. H. Slooff, Elizabeth B. Haagsma, Arie P. van den Berg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Abstract

Long-term follow-up studies on the impact of vascular events (VE) and risk factors of liver transplant recipients are scarce. In this study, 311 recipients of a first isolated liver transplant who survived at least 1 year were followed up from 1979 to 2002. The median follow-up duration was 6.2 (range1-22.7) years. Overall median survival was 18.7 [95% confidence interval (CI): 15.5-20.1] years and this was significantly lower compared with age- and sex-matched controls. Eleven (21%) of the patients had a vascular cause of death and VE were the third cause of death. VE occurred later compared with other causes of death (mean 10.3 years vs. 4.5 years, P <0.0001, 95% CI: 2.7-8.9). Systolic hypertension, systolic blood pressure, smoking, renal failure, age, hypertriglyceridemia, serum total cholesterol levels and hypercholesterolemia at the 1-year follow-up visit were associated with the occurrence of VE, but renal failure and age at 1 year after transplantation were the only independent risk factors for vascular death (hazard ratio 0.06, 95% CI: 0.01-0.41 and hazard ratio 1.17, 95% CI: 1.02-1.34, respectively). Finally, it was shown that the adequate treatment of hypertension was associated with a significant reduced risk of vascular death. Therefore, vascular risk factors should be treated aggressively to prevent VE in the long term.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalTransplant International
Volume21
Issue number1
DOIs
Publication statusPublished - Jan-2008

Keywords

  • liver transplantation
  • mortality
  • risk factors
  • survival
  • vascular events
  • CARDIOVASCULAR RISK-FACTORS
  • MYOCARDIAL-INFARCTION
  • LATE MORTALITY
  • RECIPIENTS
  • DISEASE
  • HYPERLIPIDEMIA
  • POPULATION
  • MORBIDITY
  • COMMITTEE
  • DEATH

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