Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report

Hilde M. H. Braakman; Jan Lodder; Alida A. Postma; Lambert F. R. Span; Werner H. Mess

doi:10.1186/1471-2377-10-30

Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report

Hilde M. H. Braakman^*
, Jan Lodder
, Alida A. Postma
, Lambert F. R. Span
, Werner H. Mess

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.

Case presentation: We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.

Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved.

Conclusions: This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.

Original language	English
Article number	30
Number of pages	4
Journal	BMC NEUROLOGY
Volume	10
DOIs	https://doi.org/10.1186/1471-2377-10-30
Publication status	Published - 11-May-2010
Externally published	Yes

Keywords

REVERSIBLE ENCEPHALOPATHY SYNDROME
FEATURES

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Case report Vasospasm is a significant factor in cyclosporine-induced neurotoxicityFinal publisher's version, 982 KBLicence: CC BY

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title = "Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report",

abstract = "Background: The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.Case presentation: We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved.Conclusions: This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.",

keywords = "REVERSIBLE ENCEPHALOPATHY SYNDROME, FEATURES",

author = "Braakman, \{Hilde M. H.\} and Jan Lodder and Postma, \{Alida A.\} and Span, \{Lambert F. R.\} and Mess, \{Werner H.\}",

year = "2010",

month = may,

day = "11",

doi = "10.1186/1471-2377-10-30",

language = "English",

volume = "10",

journal = "BMC NEUROLOGY",

issn = "1471-2377",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Vasospasm is a significant factor in cyclosporine-induced neurotoxicity

T2 - Case report

AU - Braakman, Hilde M. H.

AU - Lodder, Jan

AU - Postma, Alida A.

AU - Span, Lambert F. R.

AU - Mess, Werner H.

PY - 2010/5/11

Y1 - 2010/5/11

N2 - Background: The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.Case presentation: We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved.Conclusions: This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.

AB - Background: The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.Case presentation: We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved.Conclusions: This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.

KW - REVERSIBLE ENCEPHALOPATHY SYNDROME

KW - FEATURES

U2 - 10.1186/1471-2377-10-30

DO - 10.1186/1471-2377-10-30

M3 - Article

C2 - 20459819

SN - 1471-2377

VL - 10

JO - BMC NEUROLOGY

JF - BMC NEUROLOGY

M1 - 30

ER -

Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report

Abstract

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