Ventricle contact is associated with lower survival and increased peritumoral perfusion in glioblastoma

Bart Roelf Jan van Dijken, Peter Jan van Laar, Chao Li, Jiun-Lin Yan, Natalie R Boonzaier, Stephen J Price, Anouk van der Hoorn

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Abstract

OBJECTIVE The purpose of this study was to prospectively investigate outcome and differences in peritumoral MRI characteristics of glioblastomas (GBMs) that were in contact with the ventricles (ventricle-contacting tumors) and those that were not (noncontacting tumors). GBMs are heterogeneous tumors with variable survival. Lower survival is suggested for patients with ventricle-contacting tumors than for those with noncontacting tumors. This might be supported by aggressive peritumoral MRI features. However, differences in MRI characteristics of the peritumoral environment between ventricle-contacting and noncontacting GBMs have not yet been investigated.

METHODS Patients with newly diagnosed GBM underwent preoperative MRI with contrast-enhanced T1-weighted, FLAIR, diffusion-weighted, and perfusion-weighted sequences. Tumors were categorized into ventricle-contacting or noncontacting based on contrast enhancement. Survival analysis was performed using log-rank for univariate analysis and Cox regression for multivariate analysis. Normalized perfusion (relative cerebral blood volume [rCBV]) and diffusion (apparent diffusion coefficient [ADC]) values were calculated in 2 regions: the peritumoral nonenhancing FLAIR region overlapping the subventricular zone and the remaining peritumoral nonenhancing FLAIR region.

RESULTS Overall survival was significantly lower for patients with contacting tumors than for those with noncontacting tumors (434 vs 747 days, p <0.001). Progression-free survival showed a comparable trend (260 vs 375 days, p = 0.094). Multivariate analysis confirmed a survival difference for both overall survival (HR 3.930, 95% CI 1.740-8.875, p = 0.001) and progression-free survival (HR 2.506, 95% CI 1.254-5.007, p = 0.009). Peritumoral perfusion was higher in contacting than in noncontacting tumors for both FLAIR regions (p = 0.04). There was no difference in peritumoral ADC values between the 2 groups.

CONCLUSIONS Patients with ventricle-contacting tumors had poorer outcomes than patients with noncontacting tumors. This disadvantage of ventricle contact might be explained by higher peritumoral perfusion leading to more aggressive behavior.

Original languageEnglish
Pages (from-to)717-723
Number of pages7
JournalJournal of Neurosurgery
Volume131
Issue number3
Early online date19-Oct-2018
DOIs
Publication statusPublished - Sep-2019

Keywords

  • glioblastoma
  • lateral ventricles
  • survival
  • magnetic resonance imaging
  • perfusion
  • oncology
  • NEURAL STEM-CELLS
  • SUBVENTRICULAR ZONE
  • TREATMENT RESPONSE
  • RADIATION-THERAPY
  • MULTIFORME
  • MRI
  • GLIOMA
  • EXTENT
  • HETEROGENEITY
  • PREDICTION

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