Ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure: A N-13-ammonia PET study

Luis Eduardo Juarez-Orozco*, Andrea G. Monroy-Gonzalez, Friso M. van der Zant, Nick Hoogvorst, Riemer H. J. A. Slart, Remco J. J. Knol

*Corresponding author for this work

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Abstract

Background It is thought that heart failure (HF) patients may benefit from the evaluation of mechanical (dys)synchrony, and an independent inverse relationship between myocardial perfusion and ventricular synchrony has been suggested. We explore the relationship between quantitative myocardial perfusion and synchrony parameters when accounting for the presence and extent of fixed perfusion defects in patients with chronic HF. Methods We studied 98 patients with chronic HF who underwent rest and stress Nitrogen-13 ammonia PET. Multivariate analyses of covariance were performed to determine relevant predictors of synchrony (measured as bandwidth, standard deviation, and entropy). Results In our population, there were 43 (44%) women and 55 men with a mean age of 71 +/- 9.6 years. The SRS was the strongest independent predictor of mechanical synchrony variables (p <.01), among other considered predictors including: age, sex, body mass index, smoking, diabetes mellitus, dyslipidemia, hypertension, rest myocardial blood flow (MBF), and myocardial perfusion reserve (MPR). Results were similar when considering stress MBF instead of MPR. Conclusions The existence and extent of fixed perfusion defects, but not the quantitative PET myocardial perfusion parameters (sMBF and MPR), constitute a significant independent predictor of ventricular mechanical synchrony in patients with chronic HF.

Original languageEnglish
Pages (from-to)2234-2242
Number of pages9
JournalJournal of Nuclear Cardiology
Volume27
Issue number6
Early online date15-Nov-2018
DOIs
Publication statusPublished - Dec-2020

Keywords

  • Positron emission tomography
  • myocardial perfusion
  • mechanical synchrony
  • heart failure
  • CARDIAC-RESYNCHRONIZATION THERAPY
  • PHASE-ANALYSIS
  • MECHANICAL DYSSYNCHRONY
  • PROGNOSTIC VALUE
  • N-13 AMMONIA
  • BLOOD-FLOW
  • RESERVE
  • QUANTIFICATION
  • HEALTH

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