Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

George P. Liao, Eman M. M. Abdelraheem, Constantinos G. Neochoritis, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, David C. McGowan, Alexander Dömling

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Scopus)
79 Downloads (Pure)

Abstract

The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.

Original languageEnglish
Pages (from-to)4980-4983
Number of pages4
JournalOrganic letters
Volume17
Issue number20
DOIs
Publication statusPublished - 16-Oct-2015

Fingerprint

Dive into the research topics of 'Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids'. Together they form a unique fingerprint.

Cite this