Viral load in breast milk correlates with transmission of human cytomegalovirus to preterm neonates, but lactoferrin concentrations do not

BWA van der Strate*, MC Harmsen, P Schafer, PJ Swart, TH The, G Jahn, CP Speer, DKF Meijer, K Hamprecht

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

In vitro, lactoferrin (LF) strongly inhibits human cytomegalovirus (HCMV), which led us to hypothesize that in vivo HCMV might also be inhibited in secretions with high LF concentrations. In breast milk, high viral loads observed as high viral DNA titers tended to coincide with higher LF levels. However, the LF Levels did not correlate to virus transmission to preterm infants. The viral load in the transmitting group was highest compared to the nontransmitting group. We conclude that viral load in breast milk is an important factor for transmission of the virus.

Original languageEnglish
Pages (from-to)818-821
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume8
Issue number4
Publication statusPublished - Jul-2001

Keywords

  • HUMAN-IMMUNODEFICIENCY-VIRUS
  • PERIPHERAL-BLOOD LEUKOCYTES
  • IN-VITRO
  • POTENT ACTIVITY
  • INFECTION
  • PROTEINS
  • LYSOZYME
  • WHEY

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