Virus-host interplay in hepatitis B virus infection and epigenetic treatment strategies

Kai O. Hensel, Julio C. Rendon, Maria-Cristina Navas, Marianne G. Rots, Jan Postberg

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Worldwide, chronic hepatitis B virus (HBV) infection is a major health problem and no cure exists. Importantly, hepatocyte intrusion by HBV particles results in a complex deregulation of both viral and host cellular genetic and epigenetic processes. Among the attempts to develop novel therapeutic approaches against HBV infection, several options targeting the epigenomic regulation of HBV replication are gaining attention. These include the experimental treatment with 'epidrugs'. Moreover, as a targeted approach, the principle of 'epigenetic editing' recently is being exploited to control viral replication. Silencing of HBV by specific rewriting of epigenetic marks might diminish viral replication, viremia, and infectivity, eventually controlling the disease and its complications. Additionally, epigenetic editing can be used as an experimental tool to increase our limited understanding regarding the role of epigenetic modifications in viral infections. Aiming for permanent epigenetic reprogramming of the viral genome without unspecific side effects, this breakthrough may pave the roads for an ambitious technological pursuit: to start designing a curative approach utilizing manipulative molecular therapies for viral infections in vivo.

Original languageEnglish
Pages (from-to)3550-3572
Number of pages23
JournalFebs Journal
Volume284
Issue number21
DOIs
Publication statusPublished - Nov-2017

Keywords

  • cccDNA
  • CRISPR/Cas
  • DNA methylation
  • epidrugs
  • epigenome
  • epigenome editing
  • HBV
  • HBx
  • virus-host interaction
  • HEPATOCELLULAR-CARCINOMA CELLS
  • SURFACE-ANTIGEN PROMOTER
  • HEPATOCYTE NUCLEAR FACTOR-3
  • ZINC-FINGER NUCLEASES
  • ARTIFICIAL TRANSCRIPTION FACTORS
  • SMALL HETERODIMER PARTNER
  • OCCULT HBV INFECTION
  • IMPLANTED NUDE-MICE
  • IN-VIVO
  • DNA METHYLATION

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