Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications

Patrick van Rijn; Romana Schirhagl

doi:10.1002/adhm.201501000

Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications

Patrick van Rijn, Romana Schirhagl

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

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Abstract

Nanobiomaterials such as virus particles and artificial virus particles offer tremendous opportunities to develop new biomedical applications such as drug- or gene-delivery, imaging and sensing but also improve understanding of biological mechanisms. Recent advances within the field of virus-based systems give insights in how to mimic viral structures and virus assembly processes as well as understanding biodistribution, cell/tissue targeting, controlled and triggered disassembly or release and circulation times. All these factors are of high importance for virus-based functional systems. This review illustrates advances in mimicking and enhancing or controlling these aspects to a high degree toward delivery and imaging applications.

Original language	English
Pages (from-to)	1386-1400
Number of pages	15
Journal	Advanced healthcare materials
Volume	5
Issue number	12
DOIs	https://doi.org/10.1002/adhm.201501000
Publication status	Published - 22-Jun-2016

Keywords

biomedical applications
delivery
imaging
nanobiomaterials
virus particles
TOBACCO-MOSAIC-VIRUS
MRI CONTRAST AGENTS
MULTIFUNCTIONAL VIRAL NANOPARTICLES
QUARTZ-CRYSTAL MICROBALANCE
GREEN FLUORESCENT PROTEIN
TUMOR-BEARING MICE
IN-VIVO
DRUG-DELIVERY
GENE DELIVERY
POLY(ETHYLENE GLYCOL)

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title = "Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications",

abstract = "Nanobiomaterials such as virus particles and artificial virus particles offer tremendous opportunities to develop new biomedical applications such as drug- or gene-delivery, imaging and sensing but also improve understanding of biological mechanisms. Recent advances within the field of virus-based systems give insights in how to mimic viral structures and virus assembly processes as well as understanding biodistribution, cell/tissue targeting, controlled and triggered disassembly or release and circulation times. All these factors are of high importance for virus-based functional systems. This review illustrates advances in mimicking and enhancing or controlling these aspects to a high degree toward delivery and imaging applications.",

keywords = "biomedical applications, delivery, imaging, nanobiomaterials, virus particles, TOBACCO-MOSAIC-VIRUS, MRI CONTRAST AGENTS, MULTIFUNCTIONAL VIRAL NANOPARTICLES, QUARTZ-CRYSTAL MICROBALANCE, GREEN FLUORESCENT PROTEIN, TUMOR-BEARING MICE, IN-VIVO, DRUG-DELIVERY, GENE DELIVERY, POLY(ETHYLENE GLYCOL)",

author = "{van Rijn}, Patrick and Romana Schirhagl",

note = "{\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2016",

month = jun,

day = "22",

doi = "10.1002/adhm.201501000",

language = "English",

volume = "5",

pages = "1386--1400",

journal = "Advanced healthcare materials",

issn = "2192-2640",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications

AU - van Rijn, Patrick

AU - Schirhagl, Romana

PY - 2016/6/22

Y1 - 2016/6/22

N2 - Nanobiomaterials such as virus particles and artificial virus particles offer tremendous opportunities to develop new biomedical applications such as drug- or gene-delivery, imaging and sensing but also improve understanding of biological mechanisms. Recent advances within the field of virus-based systems give insights in how to mimic viral structures and virus assembly processes as well as understanding biodistribution, cell/tissue targeting, controlled and triggered disassembly or release and circulation times. All these factors are of high importance for virus-based functional systems. This review illustrates advances in mimicking and enhancing or controlling these aspects to a high degree toward delivery and imaging applications.

AB - Nanobiomaterials such as virus particles and artificial virus particles offer tremendous opportunities to develop new biomedical applications such as drug- or gene-delivery, imaging and sensing but also improve understanding of biological mechanisms. Recent advances within the field of virus-based systems give insights in how to mimic viral structures and virus assembly processes as well as understanding biodistribution, cell/tissue targeting, controlled and triggered disassembly or release and circulation times. All these factors are of high importance for virus-based functional systems. This review illustrates advances in mimicking and enhancing or controlling these aspects to a high degree toward delivery and imaging applications.

KW - biomedical applications

KW - delivery

KW - imaging

KW - nanobiomaterials

KW - virus particles

KW - TOBACCO-MOSAIC-VIRUS

KW - MRI CONTRAST AGENTS

KW - MULTIFUNCTIONAL VIRAL NANOPARTICLES

KW - QUARTZ-CRYSTAL MICROBALANCE

KW - GREEN FLUORESCENT PROTEIN

KW - TUMOR-BEARING MICE

KW - IN-VIVO

KW - DRUG-DELIVERY

KW - GENE DELIVERY

KW - POLY(ETHYLENE GLYCOL)

U2 - 10.1002/adhm.201501000

DO - 10.1002/adhm.201501000

M3 - Review article

C2 - 27119823

SN - 2192-2640

VL - 5

SP - 1386

EP - 1400

JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 12

ER -

Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications

Abstract

Keywords

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