Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications

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Abstract

Nanobiomaterials such as virus particles and artificial virus particles offer tremendous opportunities to develop new biomedical applications such as drug- or gene-delivery, imaging and sensing but also improve understanding of biological mechanisms. Recent advances within the field of virus-based systems give insights in how to mimic viral structures and virus assembly processes as well as understanding biodistribution, cell/tissue targeting, controlled and triggered disassembly or release and circulation times. All these factors are of high importance for virus-based functional systems. This review illustrates advances in mimicking and enhancing or controlling these aspects to a high degree toward delivery and imaging applications.

Original languageEnglish
Pages (from-to)1386-1400
Number of pages15
JournalAdvanced healthcare materials
Volume5
Issue number12
DOIs
Publication statusPublished - 22-Jun-2016

Keywords

  • biomedical applications
  • delivery
  • imaging
  • nanobiomaterials
  • virus particles
  • TOBACCO-MOSAIC-VIRUS
  • MRI CONTRAST AGENTS
  • MULTIFUNCTIONAL VIRAL NANOPARTICLES
  • QUARTZ-CRYSTAL MICROBALANCE
  • GREEN FLUORESCENT PROTEIN
  • TUMOR-BEARING MICE
  • IN-VIVO
  • DRUG-DELIVERY
  • GENE DELIVERY
  • POLY(ETHYLENE GLYCOL)

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