Vitamin B-12 and folate deficiency in chronic heart failure

Haye H. van der Wal, Josep Comin-Colet, Ijsbrand T. Klip, Cristina Enjuanes, Niels Grote Beverborg, Adriaan A. Voors, Waldemar Banasiak, Dirk J. van Veldhuisen, Jordi Bruguera, Piotr Ponikowski, Ewa A. Jankowska, Peter van der Meer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Abstract

Objective To determine the prevalence, clinical correlates and the effects on outcome of vitamin B-12 and folic acid levels in patients with chronic heart failure (HF).

Methods We studied an international pooled cohort comprising 610 patients with chronic HF. The main outcome measure was all-cause mortality.

Results Mean age of the patients was 68 +/- 12 years and median serum N-terminal prohormone brain natriuretic peptide level was 1801 pg/mL (IQR 705-4335). Thirteen per cent of the patients had an LVEF >45%. Vitamin B-12 deficiency (serum level

Conclusions Vitamin B-12 and folate deficiency are relatively rare in patients with chronic HF. Since no significant association was observed between mean corpuscular volume and neither vitamin B-12 nor folic acid levels, this cellular index should be used with caution in the differential diagnosis of anaemia in patients with chronic HF. In contrast to iron deficiency, vitamin B-12 and folic acid levels were not related to prognosis.

Original languageEnglish
Pages (from-to)302-310
Number of pages9
JournalHeart
Volume101
Issue number4
DOIs
Publication statusPublished - 15-Feb-2015

Keywords

  • QUALITY-OF-LIFE
  • INTRAVENOUS FERRIC CARBOXYMALTOSE
  • IRON-DEFICIENCY
  • COBALAMIN DEFICIENCY
  • PERNICIOUS-ANEMIA
  • CLINICAL-PRACTICE
  • RED-CELL
  • FAIR-HF
  • SUBANALYSIS
  • TRIAL

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