Objective To determine the prevalence, clinical correlates and the effects on outcome of vitamin B-12 and folic acid levels in patients with chronic heart failure (HF).
Methods We studied an international pooled cohort comprising 610 patients with chronic HF. The main outcome measure was all-cause mortality.
Results Mean age of the patients was 68 +/- 12 years and median serum N-terminal prohormone brain natriuretic peptide level was 1801 pg/mL (IQR 705-4335). Thirteen per cent of the patients had an LVEF >45%. Vitamin B-12 deficiency (serum level
Conclusions Vitamin B-12 and folate deficiency are relatively rare in patients with chronic HF. Since no significant association was observed between mean corpuscular volume and neither vitamin B-12 nor folic acid levels, this cellular index should be used with caution in the differential diagnosis of anaemia in patients with chronic HF. In contrast to iron deficiency, vitamin B-12 and folic acid levels were not related to prognosis.
- INTRAVENOUS FERRIC CARBOXYMALTOSE
- COBALAMIN DEFICIENCY