TY - JOUR
T1 - Vitamins B2 and B6 and Genetic Polymorphisms Related to One-Carbon Metabolism as Risk Factors for Gastric Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition
AU - Eussen, Simone J. P. M.
AU - Vollset, Stein Emil
AU - Hustad, Steinar
AU - Midttun, Oivind
AU - Meyer, Klaus
AU - Fredriksen, Ase
AU - Ueland, Per Magne
AU - Jenab, Mazda
AU - Slimani, Nadia
AU - Ferrari, Pietro
AU - Agudo, Antonio
AU - Sala, Nuria
AU - Capella, Gabriel
AU - Del Giudice, Giuseppe
AU - Palli, Domenico
AU - Boeing, Heiner
AU - Weikert, Cornelia
AU - Bueno-de-Mesquita, H. Bas
AU - Buechner, Frederike L.
AU - Carneiro, Fatima
AU - Berrino, Franco
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Berglund, Goran
AU - Manjer, Jonas
AU - Stenling, Roger
AU - Hallmans, Goeran
AU - Martinez, Carmen
AU - Arrizola, Larraitz
AU - Barricarte, Aurelio
AU - Navarro, Carmen
AU - Rodriguez, Laudina
AU - Bingham, Sheila
AU - Linseisen, Jakob
AU - Kaaks, Rudolf
AU - Overvad, Kim
AU - Tjonneland, Anne
AU - Peeters, Petra H. M.
AU - Numans, Mattijs E.
AU - Clavel-Chapelon, Francoise
AU - Boutron-Ruault, Marie-Christine
AU - Morois, Sophie
AU - Trichopoulou, Antonia
AU - Lund, Eiliv
AU - Plebani, Mario
AU - Riboli, Elio
AU - Gonzalez, Carlos A.
PY - 2010/1
Y1 - 2010/1
N2 - B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin 132 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for CC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P(trend)) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93,
AB - B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin 132 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for CC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P(trend)) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93,
KW - HELICOBACTER-PYLORI INFECTION
KW - UPPER GASTROINTESTINAL-TRACT
KW - STOMACH-CANCER
KW - METHYLENETETRAHYDROFOLATE-REDUCTASE
KW - NUTRIENT INTAKE
KW - HOMOCYSTEINE METABOLISM
KW - MTHFR POLYMORPHISMS
KW - ATROPHIC GASTRITIS
KW - PERNICIOUS-ANEMIA
KW - FOLATE-DEFICIENCY
U2 - 10.1158/1055-9965.EPI-08-1096
DO - 10.1158/1055-9965.EPI-08-1096
M3 - Article
VL - 19
SP - 28
EP - 38
JO - CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
JF - CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
SN - 1055-9965
IS - 1
ER -