Abstract
The potential for drug-drug interactions in psychiatric patients is very high as combination pharmacotherapy is often used to treat them. In this field, the hepatic cytochrome P450 enzyme system plays a major role. Recently, some new antidepressive and antipsychotic drugs have been introduced on the market. This paper reviews the hepatic metabolism of these new drugs and their potential for drug-drug interactions.
| Translated title of the contribution | An inconvenient field of drug therapy. Cytochrome P450 enzymes and interactions with new CNS agents |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 1231-1235 |
| Number of pages | 5 |
| Journal | Pharmaceutisch Weekblad |
| Volume | 134 |
| Issue number | 35 |
| Publication status | Published - 3-Sept-1999 |
Keywords
- antidepressant agent
- citalopram
- cytochrome P450
- mirtazapine
- nefazodone
- neuroleptic agent
- olanzapine
- quetiapine
- risperidone
- sertindole
- sertraline
- venlafaxine
- ziprasidone
- drug elimination
- drug inhibition
- drug metabolism
- drug potentiation
- short survey