Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial

Nanda Horeweg; Carlijn M. van der Aalst; Rozemarijn Vliegenthart; Yingru Zhao; Xueqian Xie; Ernst Th Scholten; Willem Mali; Erik Thunnissen; Carla Weenink; Harry J. M. Groen; Jan-Willem J. Lammers; Kristiaan Nackaerts; Joost van Rosmalen; Matthijs Oudkerk; Harry J. de Koning

doi:10.1183/09031936.00197712

Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial

Nanda Horeweg^*
, Carlijn M. van der Aalst
, Rozemarijn Vliegenthart
, Yingru Zhao
, Xueqian Xie
, Ernst Th Scholten
, Willem Mali
, Erik Thunnissen
, Carla Weenink
, Harry J. M. Groen
, Jan-Willem J. Lammers
, Kristiaan Nackaerts
, Joost van Rosmalen
, Matthijs Oudkerk
, Harry J. de Koning

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

214 Citations (Scopus)

Abstract

Several medical associations recommended lung cancer screening by low-dose computed tomography scanning for high-risk groups. Counselling of the candidates on the potential harms and benefits and their lung cancer risk is a prerequisite for screening.

In the NELSON trial, screenings are considered positive for (part) solid lung nodules with a volume >500 mm(3) and for (part) solid or nonsolid nodules with a volume-doubling time

458 (6%) of the 7582 participants screened had a positive screen result and 200 (2.6%) were diagnosed with lung cancer. The positive screenings had a predictive value of 40.6% and only 1.2% of all scan results were false-positive. In a period of 5.5 years, the risk of screen-detected lung cancer strongly depends on the result of the first scan: 1.0% after a negative baseline result, 5.7% after an indeterminate baseline and 48.3% after a positive baseline.

The screening strategy yielded few positive and false-positive scans with a reasonable positive predictive value. The 5.5-year lung cancer risk calculations aid clinicians in counselling candidates for lung cancer screening with low-dose computed tomography.

Original language	English
Pages (from-to)	1659-1667
Number of pages	9
Journal	European Respiratory Journal
Volume	42
Issue number	6
DOIs	https://doi.org/10.1183/09031936.00197712
Publication status	Published - Dec-2013

Keywords

PULMONARY NODULES
CT
VARIABILITY
MANAGEMENT
MORTALITY
SELECTION
DEATH

Access to Document

10.1183/09031936.00197712

Handle.net

Persistent link

Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON)
Oudkerk, M. (Creator), Groen, H. J. M. (Creator), Van Klaveren, R. J. (Creator), de Koning, H. J. (Creator), Mali, W. P. T. M. (Creator) & Lammers, J.-W. J. (Creator), University of Groningen, 2018
http://www.nelsonproject.nl/infobrochure.html
Dataset

Cite this

Horeweg, N., van der Aalst, C. M., Vliegenthart, R., Zhao, Y., Xie, X., Scholten, E. T., Mali, W., Thunnissen, E., Weenink, C., Groen, H. J. M., Lammers, J.-W. J., Nackaerts, K., van Rosmalen, J., Oudkerk, M., & de Koning, H. J. (2013). Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial. European Respiratory Journal, 42(6), 1659-1667. https://doi.org/10.1183/09031936.00197712

@article{b77d77098097413384cb7abadc344ec3,

title = "Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial",

abstract = "Several medical associations recommended lung cancer screening by low-dose computed tomography scanning for high-risk groups. Counselling of the candidates on the potential harms and benefits and their lung cancer risk is a prerequisite for screening.In the NELSON trial, screenings are considered positive for (part) solid lung nodules with a volume >500 mm(3) and for (part) solid or nonsolid nodules with a volume-doubling time458 (6\%) of the 7582 participants screened had a positive screen result and 200 (2.6\%) were diagnosed with lung cancer. The positive screenings had a predictive value of 40.6\% and only 1.2\% of all scan results were false-positive. In a period of 5.5 years, the risk of screen-detected lung cancer strongly depends on the result of the first scan: 1.0\% after a negative baseline result, 5.7\% after an indeterminate baseline and 48.3\% after a positive baseline.The screening strategy yielded few positive and false-positive scans with a reasonable positive predictive value. The 5.5-year lung cancer risk calculations aid clinicians in counselling candidates for lung cancer screening with low-dose computed tomography.",

keywords = "PULMONARY NODULES, CT, VARIABILITY, MANAGEMENT, MORTALITY, SELECTION, DEATH",

author = "Nanda Horeweg and \{van der Aalst\}, \{Carlijn M.\} and Rozemarijn Vliegenthart and Yingru Zhao and Xueqian Xie and Scholten, \{Ernst Th\} and Willem Mali and Erik Thunnissen and Carla Weenink and Groen, \{Harry J. M.\} and Lammers, \{Jan-Willem J.\} and Kristiaan Nackaerts and \{van Rosmalen\}, Joost and Matthijs Oudkerk and \{de Koning\}, \{Harry J.\}",

year = "2013",

month = dec,

doi = "10.1183/09031936.00197712",

language = "English",

volume = "42",

pages = "1659--1667",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "EUROPEAN RESPIRATORY SOC JOURNALS LTD",

number = "6",

}

Horeweg, N, van der Aalst, CM, Vliegenthart, R, Zhao, Y, Xie, X, Scholten, ET, Mali, W, Thunnissen, E, Weenink, C, Groen, HJM, Lammers, J-WJ, Nackaerts, K, van Rosmalen, J, Oudkerk, M & de Koning, HJ 2013, 'Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial', European Respiratory Journal, vol. 42, no. 6, pp. 1659-1667. https://doi.org/10.1183/09031936.00197712

TY - JOUR

T1 - Volumetric computed tomography screening for lung cancer

T2 - three rounds of the NELSON trial

AU - Horeweg, Nanda

AU - van der Aalst, Carlijn M.

AU - Vliegenthart, Rozemarijn

AU - Zhao, Yingru

AU - Xie, Xueqian

AU - Scholten, Ernst Th

AU - Mali, Willem

AU - Thunnissen, Erik

AU - Weenink, Carla

AU - Groen, Harry J. M.

AU - Lammers, Jan-Willem J.

AU - Nackaerts, Kristiaan

AU - van Rosmalen, Joost

AU - Oudkerk, Matthijs

AU - de Koning, Harry J.

PY - 2013/12

Y1 - 2013/12

N2 - Several medical associations recommended lung cancer screening by low-dose computed tomography scanning for high-risk groups. Counselling of the candidates on the potential harms and benefits and their lung cancer risk is a prerequisite for screening.In the NELSON trial, screenings are considered positive for (part) solid lung nodules with a volume >500 mm(3) and for (part) solid or nonsolid nodules with a volume-doubling time458 (6%) of the 7582 participants screened had a positive screen result and 200 (2.6%) were diagnosed with lung cancer. The positive screenings had a predictive value of 40.6% and only 1.2% of all scan results were false-positive. In a period of 5.5 years, the risk of screen-detected lung cancer strongly depends on the result of the first scan: 1.0% after a negative baseline result, 5.7% after an indeterminate baseline and 48.3% after a positive baseline.The screening strategy yielded few positive and false-positive scans with a reasonable positive predictive value. The 5.5-year lung cancer risk calculations aid clinicians in counselling candidates for lung cancer screening with low-dose computed tomography.

AB - Several medical associations recommended lung cancer screening by low-dose computed tomography scanning for high-risk groups. Counselling of the candidates on the potential harms and benefits and their lung cancer risk is a prerequisite for screening.In the NELSON trial, screenings are considered positive for (part) solid lung nodules with a volume >500 mm(3) and for (part) solid or nonsolid nodules with a volume-doubling time458 (6%) of the 7582 participants screened had a positive screen result and 200 (2.6%) were diagnosed with lung cancer. The positive screenings had a predictive value of 40.6% and only 1.2% of all scan results were false-positive. In a period of 5.5 years, the risk of screen-detected lung cancer strongly depends on the result of the first scan: 1.0% after a negative baseline result, 5.7% after an indeterminate baseline and 48.3% after a positive baseline.The screening strategy yielded few positive and false-positive scans with a reasonable positive predictive value. The 5.5-year lung cancer risk calculations aid clinicians in counselling candidates for lung cancer screening with low-dose computed tomography.

KW - PULMONARY NODULES

KW - CT

KW - VARIABILITY

KW - MANAGEMENT

KW - MORTALITY

KW - SELECTION

KW - DEATH

U2 - 10.1183/09031936.00197712

DO - 10.1183/09031936.00197712

M3 - Article

SN - 0903-1936

VL - 42

SP - 1659

EP - 1667

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 6

ER -

Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Datasets

Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON)

Cite this