Volumetric measurement of pulmonary nodules at low-dose chest CT: effect of reconstruction setting on measurement variability

Y. Wang, G.H. de Bock, R.J. van Klaveren, P. van Ooyen, W. Tukker, Y. Zhao, M.D. Dorrius, R.V. Proenca, W.J. Post, M. Oudkerk

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Abstract

To assess volumetric measurement variability in pulmonary nodules detected at low-dose chest CT with three reconstruction settings.

The volume of 200 solid pulmonary nodules was measured three times using commercially available semi-automated software of low-dose chest CT data-sets reconstructed with 1 mm section thickness and a soft kernel (A), 2 mm and a soft kernel (B), and 2 mm and a sharp kernel (C), respectively. Repeatability coefficients of the three measurements within each setting were calculated by the Bland and Altman method. A three-level model was applied to test the impact of reconstruction setting on the measured volume.

The repeatability coefficients were 8.9, 22.5 and 37.5% for settings A, B and C. Three-level analysis showed that settings A and C yielded a 1.29 times higher estimate of nodule volume compared with setting B (P = 0.03). The significant interaction among setting, nodule location and morphology demonstrated that the effect of the reconstruction setting was different for different types of nodules. Low-dose CT reconstructed with 1 mm section thickness and a soft kernel provided the most repeatable volume measurement.

A wide, nodule-type-dependent range of agreement between volume measurements with different reconstruction settings suggests strict consistency is required for serial CT studies.

Original languageEnglish
Pages (from-to)1180-1187
Number of pages8
JournalEuropean Radiology
Volume20
Issue number5
DOIs
Publication statusPublished - May-2010

Keywords

  • Multi-detector computed tomography
  • Pulmonary nodules
  • Volume measurement
  • Section thickness
  • Reconstruction kernel
  • MULTIDETECTOR ROW CT
  • PRELIMINARY EXPERIENCE
  • COMPUTED-TOMOGRAPHY
  • SLICE THICKNESS
  • TUMOR RESPONSE
  • LUNG LESIONS
  • REPRODUCIBILITY
  • INTEROBSERVER
  • PARAMETERS
  • TIME

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