von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease

Yvonne V. Sanders, Dafna Groeneveld, Karina Meijer, Karin Fijnvandraat, Marjon H. Cnossen, Johanna G. van der Bom, M. Coppens, Joke de Meris, Britta A. P. Laros-van Gorkom, Eveline P. Mauser-Bunschoten, Frank W. G. Leebeek, Jeroen Eikenboom*, WiN Study Grp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Abstract

The ratios between von Willebrand factor propeptide (VWFpp) or factor VIII activity (FVIII:C) and VWF antigen (VWF:Ag) reflect synthesis, secretion, and clearance of VWF. We aimed to define the pathophysiology of 658 patients with type 1, 2, or 3 von Willebrand disease (VWD) with VWF levels

Original languageEnglish
Pages (from-to)3006-3013
Number of pages8
JournalBlood
Volume125
Issue number19
DOIs
Publication statusPublished - 7-May-2015

Keywords

  • VWF PROPEPTIDE
  • QUANTITATIVE-ANALYSIS
  • VONWILLEBRAND-FACTOR
  • FACTOR SURVIVAL
  • ADULT PATIENTS
  • FACTOR-VIII
  • DIAGNOSIS
  • ASSAY
  • MULTIMERIZATION
  • CLEARANCE

Cite this