VPS13A is a multitasking protein at the crossroads between organelle communication and protein homeostasis

Wondwossen Melaku Yeshaw

    Research output: ThesisThesis fully internal (DIV)

    650 Downloads (Pure)

    Abstract

    Over 30 years ago, yeast vacuolar protein sorting 13 (Vps13) was discovered as one of the proteins required for carboxypeptidase Y sorting. The presence of four human Vps13 orthologues and their associations with the onsets of clinically distinct neurological and developmental disorders calls for the demand to mechanistically study each VPS13 protein in multicellular organisms. The challenge has been in defining the localization and functional contributions of each VPS13 family member in molecular pathways. Data presented in this thesis attempts to uncover the subcellular localization and molecular functions of VPS13A in healthy tissue and the consequences of its absence in a Drosophila and human cell ChAc models.
    Translated title of the contributionVPS13A is een multitasking-eiwit op het kruispunt tussen organelcommunicatie en eiwithomeostase
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Sibon, Ody, Supervisor
    Award date18-Jun-2018
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-0767-8
    Electronic ISBNs978-94-034-0768-5
    Publication statusPublished - 2018

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