Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding

Aaffien C. Reijne, Alzbeta Talarovicova, Alex Coolen, Jan E. Bruggink, Jolita Ciapaite, Aycha Bleeker, Albert K. Groen, Dirk Jan Reijngoud, Barbara M. Bakker, Gertjan Van Dijk*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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BACKGROUND: Lifelong consumption of a Western-style diet is a risk factor for developing metabolic disorders and therefore impairs healthy aging. Dietary restriction (DR) could delay the onset of age-related diseases and prolong life span, however, the extent to which this depends on diet type is poorly understood.

OBJECTIVE: To study whether feeding a Western-style diet affects the healthy aging benefits of DR.

METHODS: Mice fed a Western-style diet (ad libitum and DR) were compared to those fed a standard healthy diet (ad libitum and DR). Survival and several metabolic and endocrine parameters were analyzed.

RESULTS: Lifelong consumption of a Western-style diet resulted in increased adiposity, elevated triglyceride levels in plasma, higher homeostatic model assessment-insulin resistance and higher resting metabolic rate in mice compared to the standard diet group. This was accompanied by reduced survival in the Western-style diet group. DR irrespective of diet type improved abovementioned parameters.

CONCLUSIONS: Lifelong restricted consumption of Western-style diet led to improved metabolic and endocrine parameters, and increased survival compared to the ad libitum Western-style diet group. Interestingly, the survival was comparable in restricted Western-style and standard diet groups, suggesting that reduced food intake rather than diet composition play more important role in promoting longevity/survival.

Original languageEnglish
Pages (from-to)61-74
Number of pages14
JournalNutrition and Healthy Aging
Issue number1-2
Publication statusPublished - 3-Aug-2022


  • aging
  • caloric restriction
  • Diet
  • diet therapy
  • hormones
  • metabolism
  • survival
  • western


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