Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding

Aaffien C. Reijne; Alzbeta Talarovicova; Alex Coolen; Jan E. Bruggink; Jolita Ciapaite; Aycha Bleeker; Albert K. Groen; Dirk Jan Reijngoud; Barbara M. Bakker; Gertjan Van Dijk

doi:10.3233/NHA-220163

Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding

Aaffien C. Reijne, Alzbeta Talarovicova, Alex Coolen, Jan E. Bruggink, Jolita Ciapaite, Aycha Bleeker, Albert K. Groen, Dirk Jan Reijngoud, Barbara M. Bakker, Gertjan Van Dijk^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Lifelong consumption of a Western-style diet is a risk factor for developing metabolic disorders and therefore impairs healthy aging. Dietary restriction (DR) could delay the onset of age-related diseases and prolong life span, however, the extent to which this depends on diet type is poorly understood.

OBJECTIVE: To study whether feeding a Western-style diet affects the healthy aging benefits of DR.

METHODS: Mice fed a Western-style diet (ad libitum and DR) were compared to those fed a standard healthy diet (ad libitum and DR). Survival and several metabolic and endocrine parameters were analyzed.

RESULTS: Lifelong consumption of a Western-style diet resulted in increased adiposity, elevated triglyceride levels in plasma, higher homeostatic model assessment-insulin resistance and higher resting metabolic rate in mice compared to the standard diet group. This was accompanied by reduced survival in the Western-style diet group. DR irrespective of diet type improved abovementioned parameters.

CONCLUSIONS: Lifelong restricted consumption of Western-style diet led to improved metabolic and endocrine parameters, and increased survival compared to the ad libitum Western-style diet group. Interestingly, the survival was comparable in restricted Western-style and standard diet groups, suggesting that reduced food intake rather than diet composition play more important role in promoting longevity/survival.

Original language	English
Pages (from-to)	61-74
Number of pages	14
Journal	Nutrition and Healthy Aging
Volume	7
Issue number	1-2
DOIs	https://doi.org/10.3233/NHA-220163
Publication status	Published - 3-Aug-2022

Keywords

aging
caloric restriction
Diet
diet therapy
hormones
metabolism
survival
western

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10.3233/NHA-220163Licence: CC BY-NC

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Replication Data for: Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding
Reijne, A. C. (Creator), Talarovicova, A. (Creator), Coolen, A. (Creator), Bruggink, J. E. (Creator), Ciapaite, J. (Creator), Bleeker, A. (Creator), Groen, B. (Creator), Reijngoud, D.-J. (Creator), Bakker, B. (Creator) & Van Dijk, G. (Creator), DataverseNL, 2023
DOI: 10.34894/irxdxh
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@article{ebbfc90194994ded991c902524306ed7,

title = "Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding",

abstract = "BACKGROUND: Lifelong consumption of a Western-style diet is a risk factor for developing metabolic disorders and therefore impairs healthy aging. Dietary restriction (DR) could delay the onset of age-related diseases and prolong life span, however, the extent to which this depends on diet type is poorly understood.OBJECTIVE: To study whether feeding a Western-style diet affects the healthy aging benefits of DR.METHODS: Mice fed a Western-style diet (ad libitum and DR) were compared to those fed a standard healthy diet (ad libitum and DR). Survival and several metabolic and endocrine parameters were analyzed.RESULTS: Lifelong consumption of a Western-style diet resulted in increased adiposity, elevated triglyceride levels in plasma, higher homeostatic model assessment-insulin resistance and higher resting metabolic rate in mice compared to the standard diet group. This was accompanied by reduced survival in the Western-style diet group. DR irrespective of diet type improved abovementioned parameters.CONCLUSIONS: Lifelong restricted consumption of Western-style diet led to improved metabolic and endocrine parameters, and increased survival compared to the ad libitum Western-style diet group. Interestingly, the survival was comparable in restricted Western-style and standard diet groups, suggesting that reduced food intake rather than diet composition play more important role in promoting longevity/survival. ",

keywords = "aging, caloric restriction, Diet, diet therapy, hormones, metabolism, survival, western",

author = "Reijne, {Aaffien C.} and Alzbeta Talarovicova and Alex Coolen and Bruggink, {Jan E.} and Jolita Ciapaite and Aycha Bleeker and Groen, {Albert K.} and Reijngoud, {Dirk Jan} and Bakker, {Barbara M.} and {Van Dijk}, Gertjan",

note = "Funding Information: Barbara M. Bakker was supported by a Rosalind Franklin Fellowship for the University of Groningen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: This work was supported by a grant from the Netherlands Organization for Scientific Research (NWO, grant no. 853.00.110); https://www.nwo.nl/onderzoek-en-resultaten/onderzoeksprojecten/94/2300159494.html . Publisher Copyright: {\textcopyright} 2022 - The authors. Published by IOS Press.",

year = "2022",

month = aug,

day = "3",

doi = "10.3233/NHA-220163",

language = "English",

volume = "7",

pages = "61--74",

journal = "Nutrition and Healthy Aging",

issn = "2451-9480",

publisher = "IOS Press",

number = "1-2",

}

TY - JOUR

T1 - Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding

AU - Reijne, Aaffien C.

AU - Talarovicova, Alzbeta

AU - Coolen, Alex

AU - Bruggink, Jan E.

AU - Ciapaite, Jolita

AU - Bleeker, Aycha

AU - Groen, Albert K.

AU - Reijngoud, Dirk Jan

AU - Bakker, Barbara M.

AU - Van Dijk, Gertjan

N1 - Funding Information: Barbara M. Bakker was supported by a Rosalind Franklin Fellowship for the University of Groningen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: This work was supported by a grant from the Netherlands Organization for Scientific Research (NWO, grant no. 853.00.110); https://www.nwo.nl/onderzoek-en-resultaten/onderzoeksprojecten/94/2300159494.html . Publisher Copyright: © 2022 - The authors. Published by IOS Press.

PY - 2022/8/3

Y1 - 2022/8/3

N2 - BACKGROUND: Lifelong consumption of a Western-style diet is a risk factor for developing metabolic disorders and therefore impairs healthy aging. Dietary restriction (DR) could delay the onset of age-related diseases and prolong life span, however, the extent to which this depends on diet type is poorly understood.OBJECTIVE: To study whether feeding a Western-style diet affects the healthy aging benefits of DR.METHODS: Mice fed a Western-style diet (ad libitum and DR) were compared to those fed a standard healthy diet (ad libitum and DR). Survival and several metabolic and endocrine parameters were analyzed.RESULTS: Lifelong consumption of a Western-style diet resulted in increased adiposity, elevated triglyceride levels in plasma, higher homeostatic model assessment-insulin resistance and higher resting metabolic rate in mice compared to the standard diet group. This was accompanied by reduced survival in the Western-style diet group. DR irrespective of diet type improved abovementioned parameters.CONCLUSIONS: Lifelong restricted consumption of Western-style diet led to improved metabolic and endocrine parameters, and increased survival compared to the ad libitum Western-style diet group. Interestingly, the survival was comparable in restricted Western-style and standard diet groups, suggesting that reduced food intake rather than diet composition play more important role in promoting longevity/survival.

AB - BACKGROUND: Lifelong consumption of a Western-style diet is a risk factor for developing metabolic disorders and therefore impairs healthy aging. Dietary restriction (DR) could delay the onset of age-related diseases and prolong life span, however, the extent to which this depends on diet type is poorly understood.OBJECTIVE: To study whether feeding a Western-style diet affects the healthy aging benefits of DR.METHODS: Mice fed a Western-style diet (ad libitum and DR) were compared to those fed a standard healthy diet (ad libitum and DR). Survival and several metabolic and endocrine parameters were analyzed.RESULTS: Lifelong consumption of a Western-style diet resulted in increased adiposity, elevated triglyceride levels in plasma, higher homeostatic model assessment-insulin resistance and higher resting metabolic rate in mice compared to the standard diet group. This was accompanied by reduced survival in the Western-style diet group. DR irrespective of diet type improved abovementioned parameters.CONCLUSIONS: Lifelong restricted consumption of Western-style diet led to improved metabolic and endocrine parameters, and increased survival compared to the ad libitum Western-style diet group. Interestingly, the survival was comparable in restricted Western-style and standard diet groups, suggesting that reduced food intake rather than diet composition play more important role in promoting longevity/survival.

KW - aging

KW - caloric restriction

KW - Diet

KW - diet therapy

KW - hormones

KW - metabolism

KW - survival

KW - western

U2 - 10.3233/NHA-220163

DO - 10.3233/NHA-220163

M3 - Article

AN - SCOPUS:85140830930

SN - 2451-9480

VL - 7

SP - 61

EP - 74

JO - Nutrition and Healthy Aging

JF - Nutrition and Healthy Aging

IS - 1-2

ER -

Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding

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