What Are the Limits to the Size of Effective Dynamic Combinatorial Libraries?

Peter T. Corbett; Sijbren Otto; Jeremy K.M. Sanders

doi:10.1021/ol049398k

What Are the Limits to the Size of Effective Dynamic Combinatorial Libraries?

Peter T. Corbett, Sijbren Otto, Jeremy K.M. Sanders

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

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Abstract

Using simple computer simulations of model dynamic combinatorial libraries, we show that the best binders can be amplified to useful concentrations in libraries containing 10-10^6 compounds.

Original language	English
Number of pages	3
Journal	Organic letters
Volume	6
Issue number	11
DOIs	https://doi.org/10.1021/ol049398k
Publication status	Published - 2004

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@article{f80eaa6a913244d5be05af0ec95fca68,

title = "What Are the Limits to the Size of Effective Dynamic Combinatorial Libraries?",

abstract = "Using simple computer simulations of model dynamic combinatorial libraries, we show that the best binders can be amplified to useful concentrations in libraries containing 10-10^6 compounds.",

author = "Corbett, {Peter T.} and Sijbren Otto and Sanders, {Jeremy K.M.}",

note = "Relation: http://www.rug.nl/scheikunde/onderzoek/scholen/stratingh/index date_submitted:2009 Rights: University of Groningen, Stratingh Institute for Chemistry",

year = "2004",

doi = "10.1021/ol049398k",

language = "English",

volume = "6",

journal = "Organic letters",

issn = "1523-7052",